Wakelin D, Selby G R
Parasitology. 1976 Feb;72(1):41-50. doi: 10.1017/s0031182000043171.
Lethal irradiation (850 rads) of mice made resistant to Trichuris muris markedly depressed their ability to expel a challenge infection. Expulsion was restored within 7-10 days when MLNC from uninfected mice were transferred on the day of infection, but no significant restoration was evident after transfer of immune serum. Transfer of BM alone had no restorative effect within 10 days and no synergism was seen when both BM and MLNC were transferred. MLNC from uninfected donors did not restore challenge expulsion when transfer was delayed until day 7 and the mice were killed 3 days later, although MLNC from resistant donors were effective within this time. When irradiated mice were given BM and the challenge infection allowed to continue for 15 days expulsion was restored, as it was when challenge was delayed for 7 days after BM transfer in thymectomized mice. The results confirm that expulsion of T. muris involves both antibody-mediated and lymphoid cell-mediated phases and offer no evidence for the involvement of other cell types.
对已对鼠鞭虫产生抗性的小鼠进行致死剂量照射（850拉德），会显著降低它们驱除再次感染虫体的能力。在感染当天转移未感染小鼠的肠系膜淋巴结细胞（MLNC）后，7 - 10天内驱除能力得以恢复，但转移免疫血清后未观察到明显的恢复。单独转移骨髓在10天内没有恢复作用，同时转移骨髓和MLNC也未出现协同作用。当转移延迟至第7天且3天后处死小鼠时，来自未感染供体的MLNC不能恢复对再次感染的驱除能力，尽管来自抗性供体的MLNC在此期间是有效的。当给受照射小鼠输入骨髓并让再次感染持续15天时，驱除能力得以恢复，在胸腺切除小鼠中骨髓转移后将再次感染延迟7天时也是如此。结果证实，驱除鼠鞭虫涉及抗体介导和淋巴细胞介导两个阶段，且没有证据表明其他细胞类型参与其中。
