Selby G R, Wakelin D
Parasitology. 1975 Aug;71(1):77-85. doi: 10.1017/s0031182000053166.
Mice infected with Trichuris muris during lactation were unable to expel the infection at the normal time, but expulsion occurred when lactation was terminated. Suppression of expulsion was uniform in mice suckling more than five young but variable with smaller litters. Mice exposed to a primary infection while lactating were shown to have serum antibodies capable of passively transferring immunity to recipient mice and showed near normal immunity to a secondary infection given after lactation had ceased. Acquired immunity to T. muris was also suppressed by lactation, but the worms which became established in lactating resistant mice were fewer and smaller than those in non-lactating, non-resistant controls. It is suggested that the suppressive effect of lactation in this host-parasite relationship is exerted on the second, lymphoid cell-mediated phase of worm expulsion.
在哺乳期感染毛首鞭形线虫的小鼠无法在正常时间排出感染，但在哺乳期结束时会发生排虫。在哺乳超过五只幼崽的小鼠中，排虫抑制是一致的，但在较小窝仔数的小鼠中则有所不同。研究表明，在哺乳期受到初次感染的小鼠具有能够将免疫力被动转移给受体小鼠的血清抗体，并且在哺乳期结束后对二次感染表现出接近正常的免疫力。哺乳期也会抑制对毛首鞭形线虫的获得性免疫，但在具有抗性的哺乳期小鼠中定植的蠕虫比未哺乳的非抗性对照小鼠中的蠕虫更少、更小。有人认为，在这种宿主 - 寄生虫关系中，哺乳期的抑制作用作用于蠕虫排出的第二个、由淋巴细胞介导的阶段。
