Wohns R N, Wyler A R
J Neurosurg. 1979 Oct;51(4):507-9. doi: 10.3171/jns.1979.51.4.0507.
We are reporting a retrospective study of 62 patients whose head injury was sufficiently severe to cause a high probability of posttraumatic epilepsy. Of 50 patients treated with phenytoin, 10% developed epilepsy of late onset. Twelve patients not treated with phenytoin but who had head injuries of equal magnitude had a 50% incidence of epilepsy. These data from a highly selected group of patients with severe head injuries confirm the bias that treatment with phenytoin decreases the incidence of posttraumatic epilepsy.
我们报告了一项对62例头部损伤严重到足以导致创伤后癫痫高发生率患者的回顾性研究。在50例接受苯妥英治疗的患者中，10%发生迟发性癫痫。12例未接受苯妥英治疗但头部损伤程度相同的患者癫痫发生率为50%。这些来自高度选择的严重头部损伤患者组的数据证实了苯妥英治疗可降低创伤后癫痫发生率这一偏差。
