Dunn L T, Foy P M
Walton Centre for Neurology and Neurosurgery, Liverpool.
Ann R Coll Surg Engl. 1994 May;76(3):147-9.
The evidence for and against the prophylactic use of anticonvulsants and antibiotics in head injury is reviewed. There is a lack of blinded placebo-controlled trials in this area. On balance there is no compelling evidence to support the use of either anticonvulsant or antibiotic prophylaxis in head injury, with the possible exception of antibiotic prophylaxis in compound depressed skull fractures and penetrating brain injuries.
本文综述了支持和反对在头部损伤中预防性使用抗惊厥药和抗生素的证据。该领域缺乏双盲安慰剂对照试验。总体而言，没有令人信服的证据支持在头部损伤中使用抗惊厥药或抗生素进行预防，复合性凹陷性颅骨骨折和穿透性脑损伤中预防性使用抗生素可能是个例外。
