Brown K H, Gaffar A, Alamgir S M
J Pediatr. 1979 Oct;95(4):651-6. doi: 10.1016/s0022-3476(79)80790-8.
All children with evidence of xerophthalmia who were admitted to an inpatient facility for treatment of severe protein-calorie malnutrition and its complications were compared to other inpatients with severe PCM but free from signs or symptoms of vitamin A deficiency. Xerophthalmic inpatients were older and had more severe hypoproteinemia than inpatients without eye signs, and were more undernourished by anthropometric criteria than a comparison group matched for age, sex, and type of PCM. Children with more severe eye lesions were more retarded in growth than those with minimal ocular signs. All inpatients had high rates of bacterial infections, regardless of their vitamin status. However, xerophthalmic children had a highly significant increase in the rate of positive urine cultures. Mortality rates were similar in all study groups.
所有因严重蛋白质 - 热量营养不良及其并发症而入住住院治疗机构的干眼症患儿，与其他患有严重蛋白质 - 热量营养不良但无维生素A缺乏体征或症状的住院患者进行了比较。患有干眼症的住院患者比没有眼部体征的住院患者年龄更大，低蛋白血症更严重，并且根据人体测量标准，比按年龄、性别和蛋白质 - 热量营养不良类型匹配的对照组营养不良程度更高。眼部病变更严重的儿童比眼部体征轻微的儿童生长发育更迟缓。所有住院患者的细菌感染率都很高，无论其维生素状况如何。然而，患有干眼症的儿童尿培养阳性率显著增加。所有研究组的死亡率相似。
