Biswas R, Biswas A B, Manna B, Bhattacharya S K, Dey R, Sarkar S
Nilratan Sircar Medical College and Hospitals, Calcutta, India.
Eur J Epidemiol. 1994 Feb;10(1):57-61. doi: 10.1007/BF01717453.
To determine the effect of a massive single oral dose of vitamin A (200,000 IU) supplementation on diarrhoea and acute respiratory infection (ARI), a double-blind placebo controlled trial involving 174 children under six years of age (excluding infants) was carried out in a Calcutta slum community. Ninety-one children received vitamin A supplementation (experimental group) and 83 children received a placebo (control group). All the children were followed up for six months by active fortnightly surveillance for occurrence of diarrhoea or ARI and their duration. There was no statistically significant difference in the incidence of diarrhoeal episodes or ARI. However, there was a significant difference (p < 0.05) in the average duration of diarrhoea per episode (2.1 vs. 3 days) between the experimental and control groups. Possible beneficial effects of a single oral dose of vitamin A supplementation on the incidence of diarrhoea and ARI could not be demonstrated in the present study.
为确定单次大剂量口服维生素A（200,000国际单位）补充剂对腹泻和急性呼吸道感染（ARI）的影响，在加尔各答一个贫民窟社区开展了一项双盲安慰剂对照试验，涉及174名6岁以下儿童（不包括婴儿）。91名儿童接受维生素A补充剂（试验组），83名儿童接受安慰剂（对照组）。通过每两周主动监测腹泻或ARI的发生情况及其持续时间，对所有儿童进行了为期6个月的随访。腹泻发作或ARI的发生率没有统计学上的显著差异。然而，试验组和对照组之间每次腹泻的平均持续时间存在显著差异（p < 0.05）（2.1天对3天）。本研究未能证明单次口服维生素A补充剂对腹泻和ARI发生率可能存在的有益影响。
