Anderson K E, Ingemarsson I, Persson C G
Acta Obstet Gynecol Scand. 1975;54(2):165-72. doi: 10.3109/00016347509156750.
The effects of the selective beta-2-receptor stimulator terbutaline on the activity of gravid, human myometrium were investigated in vitro and in vivo, before and after administration of different beta-receptor blockers. Terbutaline, 0.2-1.0 mu-g/ml, inhibited the spontaneous contractile activity of isolated strips of myometrium. This effect was unaffected by the selective beta-a-receptor blockers practolol, 1 mu-g/ml, and H 93/26, 1 mu-g/ml. However, the non-selective blocker propranolol, 0.1 mu-g/ml, completely inhibited the terbutaline effects. The in vitro effects of terbutaline could be correlated with findings in vivo. Intra-uterine pressure was recorded in 4 pregnant women at term. Infusion of terbutaline, 10-15 mu-g/min, for 20-40 min, effectively inhibited both spontaneous and oxytocin-stimulated uterine activity. There was a moderate increase in maternal heart rate, but no consistent effect on maternal blood pressure. Fetal heart rate was little affected. The uterine effects of terbuline were not influenced by practolol, 5-20 mg i.v., but completely inhibited by propranolol, 1-2 mg i.v. The results suggest that terbutaline inhibits uterine motility by effects on uterine beta-2-receptors and that it can be given in clinically effective doses without adverse circulatory effects on mother or fetus.
在给予不同β受体阻滞剂之前和之后，在体外和体内研究了选择性β₂受体激动剂特布他林对妊娠的人子宫肌层活性的影响。0.2 - 1.0μg/ml的特布他林抑制了离体子宫肌层条带的自发收缩活性。这种作用不受1μg/ml的选择性β₁受体阻滞剂普拉洛尔和1μg/ml的H 93/26的影响。然而，0.1μg/ml的非选择性阻滞剂普萘洛尔完全抑制了特布他林的作用。特布他林的体外作用与体内研究结果相关。记录了4名足月孕妇的宫内压力。以10 - 15μg/分钟的速度输注特布他林20 - 40分钟，可有效抑制自发的和催产素刺激的子宫活动。孕妇心率有适度增加，但对孕妇血压没有持续影响。胎儿心率几乎未受影响。特布他林对子宫的作用不受静脉注射5 - 20mg普拉洛尔的影响，但被静脉注射1 - 2mg普萘洛尔完全抑制。结果表明，特布他林通过作用于子宫β₂受体来抑制子宫运动，并且可以给予临床有效剂量而不会对母亲或胎儿产生不良循环影响。
