McDevitt D G, Wallace R J, Roberts A, Whitfield C R
Br J Obstet Gynaecol. 1975 Jun;82(6):442-8. doi: 10.1111/j.1471-0528.1975.tb00667.x.
Intravenous salbutamol, a beta-adrenoceptor stimulant, given to nine patients in normal labour, with continous monitoring of uterine activity and of the maternal and fetal cardiovascular systems, was shown to decrease uterine activity significantly; maternal and fetal heart rates were significantly increased, and maternal systolic and diastolic arterial pressures were significantly decreased during the infusion, although no treatment had to be discontinued because of these effects. Apart from worsening of low back pain during the infusion in one patients, subjective side-effects were trival. With the salbutamol infusion continued at an effective maintenance rate, the carioselective beta-adrenoceptor blocking drug, practolol, given intravenously, reduced the maternal heart rate (although not significantly) but it did not alter the fetal heart rate; it also appeared to interfere transiently with the inhibiting action of salbutamol on uterine activity, but cerevical dilatation was arrested until the salbutamol infusion was discontinued. At least in five patients, labour remained suppressed until oxytoxin was infused intravenously.
对9名正常分娩的产妇静脉注射β-肾上腺素能受体兴奋剂沙丁胺醇，并持续监测子宫活动以及母体和胎儿的心血管系统，结果显示该药能显著降低子宫活动；静脉输注期间，母体和胎儿心率显著增加，母体收缩压和舒张压显著降低，不过并未因这些效应而中断任何治疗。除1名患者在输注期间腰痛加重外，主观副作用轻微。在以有效维持速率持续输注沙丁胺醇的情况下，静脉注射具有心脏选择性的β-肾上腺素能受体阻断药心得宁，可降低母体心率（尽管不显著），但未改变胎儿心率；它似乎还会短暂干扰沙丁胺醇对子宫活动的抑制作用，但在沙丁胺醇输注停止前，宫颈扩张停止。至少在5名患者中，产程一直受到抑制，直到静脉输注催产素。
