Besson C, Gonin C, Brebion A, Delaunay C, Panelatti G, Plumelle Y
Internal Medicine Unit, University Hospital, Forte de France, Martinique, France.
Leukemia. 2001 May;15(5):828-31. doi: 10.1038/sj.leu.2402040.
A registry of hematological malignancies is held in the unit of cytology of the University Hospital of Martinique. Human T cell lymphotropic virus type-1 (HTLV1) is endemic in this island. We determined the incidence and epidemiological features of hematological malignancies from the 715 new cases diagnosed between 1990 and 1998 among the adult population. Incidence rates per year were steady during this period. The most frequent hematological malignancies were multiple myeloma (MM) (34%), followed by non-Hodgkin's lymphoma (NHL) (23%). Among the cases of NHL with an immunohistological study, 57% had a T cell phenotype. Among these 61% were adult T cell leukemia/lymphoma. Epidemiological data on hematological malignancies in the West Indies has not been previously reported. There are two striking differences with other population-based registries: a high incidence of MM (5/100000) and a high proportion of T cell NHL among NHL (57%). The high proportion of T cell NHL is probably due to the high incidence of ATL. A low incidence of B cell NHL might also contribute to this effect. The increased incidence of MM in West Indies had not been previously reported. A similar high incidence of MM has been reported among Afro-Americans in the USA.
马提尼克大学医院细胞学部门保存了一份血液系统恶性肿瘤登记册。1型人类嗜T细胞病毒（HTLV1）在该岛呈地方流行性。我们确定了1990年至1998年间在成年人群中诊断出的715例新病例中血液系统恶性肿瘤的发病率和流行病学特征。在此期间，每年的发病率保持稳定。最常见的血液系统恶性肿瘤是多发性骨髓瘤（MM）（34%），其次是非霍奇金淋巴瘤（NHL）（23%）。在进行免疫组织学研究的NHL病例中，57%具有T细胞表型。在这些病例中，61%为成人T细胞白血病/淋巴瘤。西印度群岛血液系统恶性肿瘤的流行病学数据此前尚未见报道。与其他基于人群的登记数据有两个显著差异：MM的高发病率（5/100000）以及NHL中T细胞NHL的高比例（57%）。T细胞NHL的高比例可能归因于成人T细胞白血病/淋巴瘤的高发病率。B细胞NHL的低发病率也可能对此有影响。西印度群岛MM发病率的增加此前未见报道。在美国非裔美国人中也报道了类似的MM高发病率。
