Ramdial P K, Madaree A
Department of Pathology, Faculty of Medicine, University of Natal, Private Bag 7, Congella, 4013, South Africa.
Pediatr Dev Pathol. 2001 May-Jun;4(3):267-75. doi: 10.1007/s100240010140.
Although solitary fibrous tumor (SFT) was originally described as a pleural tumor, an increasing number of extrapleural sites of SFTs have been documented. This has been attributed not only to the heightened awareness of the spectrum of histopathological features that characterizes SFTs but also to the recognition of the role of CD34 immunostaining in soft tissue tumors in general, and in SFTs in particular. Despite the large number of documented extrapleural SFTs in adults, cranial SFTs are rare, having been documented in the meninges, scalp, and infratemporal fossa. Extrapleural SFTs are, to date, an unrecognized entity in children. We document an aggressive fibrous scalp lesion in a 30-month-old female child that demonstrated features common to benign cranial fasciitis and SFT. However, based on bright, diffuse CD34 antigen immunopositivity, a diagnosis of SFT was made. The need to include the CD34 antigen stain in a panel of immunohistochemical markers used to assess spindle cell lesions of childhood is emphasized.
虽然孤立性纤维瘤（SFT）最初被描述为一种胸膜肿瘤，但越来越多的SFT发生于胸膜外部位的情况已有文献记载。这不仅归因于对SFT特征性组织病理学特征谱的认识提高，还归因于一般软组织肿瘤尤其是SFT中CD34免疫染色作用的认识。尽管成人胸膜外SFT的文献记载数量众多，但颅骨SFT却很罕见，仅在脑膜、头皮和颞下窝有过记载。迄今为止，胸膜外SFT在儿童中还是一种未被认识的实体。我们报告了一名30个月大女童的侵袭性头皮纤维性病变，该病变表现出良性颅骨筋膜炎和SFT的共同特征。然而，基于明亮、弥漫性的CD34抗原免疫阳性，最终诊断为SFT。强调了在用于评估儿童期梭形细胞病变的一组免疫组化标志物中应包括CD34抗原染色。
