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大腿部孤立性纤维瘤:文献综述

Solitary fibrous tumor in the thigh: review of the literature.

作者信息

Anders J O, Aurich M, Lang T, Wagner A

机构信息

Department of Orthopaedic Surgery, Friedrich-Schiller-University Jena, Waldkrankenhaus Rudolf Elle Eisenberg, Klosterlausnitzerstr. 81, 07607 Eisenberg, Germany.

出版信息

J Cancer Res Clin Oncol. 2006 Feb;132(2):69-75. doi: 10.1007/s00432-005-0055-7. Epub 2005 Nov 9.

Abstract

Solitary fibrous tumors (SFT) of extremities, especially the thighs are very rare. Despite SFTs are generally benign, well-circumscribed soft tissue tumors new cases should be presented and followed up carefully to monitor their biological behavior. In general for tumor classification a biopsy is state of the art. Histological including immunohistochemical patterns for SFTs are defined. MRI and ultrasound are not sufficient for differential diagnosis. Once property identified and defined by size and location, resection with intact tumor capsule may result in full recovery of the patient. Reviewing the literature there are no validated reasons for a wider resection. The current patient was a 41-year-old male. Four years after an arthroscopy of the left knee the patient has been suffering an ongoing swelling of the lateral thigh. Because MRI scan data suggested a synovial sarcoma a biopsy was performed. The tumor was classified as a benign SFT. The diagnosis based on histological findings and the presence of the positive immunohistochemical markers Vimentin, CD34, and CD99. The complete tumor resection with intact capsule was achieved in a final operation. Clinical and in MRI after 54-month outcome period there were no local recurrences.

摘要

四肢孤立性纤维瘤(SFT),尤其是大腿部的非常罕见。尽管SFT通常为良性、边界清晰的软组织肿瘤,但新病例仍应予以报告并仔细随访,以监测其生物学行为。一般来说,肿瘤分类需进行活检,这是目前的标准做法。SFT的组织学特征包括免疫组化模式已明确。MRI和超声不足以进行鉴别诊断。一旦通过大小和位置明确肿瘤性质,完整切除肿瘤包膜可能使患者完全康复。查阅文献发现,没有经过验证的理由支持更广泛的切除。本例患者为41岁男性。左膝关节镜检查4年后,患者大腿外侧持续肿胀。由于MRI扫描数据提示为滑膜肉瘤,遂进行了活检。肿瘤被分类为良性SFT。诊断基于组织学检查结果以及阳性免疫组化标志物波形蛋白、CD34和CD99的存在。最终手术实现了完整包膜下的肿瘤完整切除。在54个月的观察期后,临床检查及MRI均未发现局部复发。

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