Chemical Constituents and Anticancer Activities of Marine-Derived Fungus .

The fungal genus is a rich source of structurally diverse secondary metabolites with remarkable pharmaceutical properties. The chemical constituents and anticancer activities of the marine-derived fungus have never been investigated. In this study, a bioactivity-guided investigation led to the isolation of eleven compounds, including trichodermamide A (), trichodermamide B (), aspergillazine A (), DC1149B (), ergosterol peroxide (), cerebrosides D/C (), 5-hydroxy-2,3-dimethyl-7-methoxychromone (), nafuredin A (), and harzianumols E/F (/). Their structures were identified by using various spectroscopic techniques and compared to those in the literature. Notably, compounds and - were reported for the first time from this species. Evaluation of the anticancer activities of all isolated compounds was carried out. Compounds , , and were the most active antiproliferative compounds against three cancer cell lines (human myeloma KMS-11, colorectal HT-29, and pancreas PANC-1). Intriguingly, compound exhibited anti-austerity activity with an IC of 22.43 μM against PANC-1 cancer cells under glucose starvation conditions, while compound did not.