Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Osaka, Japan.
Department of Chemistry, Faculty of Science, Lampung University, Jl. Prof. Dr. Sumantri Brodjonegoro No. 1, Bandar Lampung 35145, Lampung, Indonesia.
Molecules. 2024 Apr 29;29(9):2048. doi: 10.3390/molecules29092048.
The fungal genus is a rich source of structurally diverse secondary metabolites with remarkable pharmaceutical properties. The chemical constituents and anticancer activities of the marine-derived fungus have never been investigated. In this study, a bioactivity-guided investigation led to the isolation of eleven compounds, including trichodermamide A (), trichodermamide B (), aspergillazine A (), DC1149B (), ergosterol peroxide (), cerebrosides D/C (), 5-hydroxy-2,3-dimethyl-7-methoxychromone (), nafuredin A (), and harzianumols E/F (/). Their structures were identified by using various spectroscopic techniques and compared to those in the literature. Notably, compounds and - were reported for the first time from this species. Evaluation of the anticancer activities of all isolated compounds was carried out. Compounds , , and were the most active antiproliferative compounds against three cancer cell lines (human myeloma KMS-11, colorectal HT-29, and pancreas PANC-1). Intriguingly, compound exhibited anti-austerity activity with an IC of 22.43 μM against PANC-1 cancer cells under glucose starvation conditions, while compound did not.
是一种富含结构多样的次级代谢产物的真菌属，具有显著的药物特性。海洋来源的真菌的化学成分和抗癌活性从未被研究过。在这项研究中，一种基于生物活性的研究导致了 11 种化合物的分离，包括 Trichodermamide A ()、Trichodermamide B ()、Aspergillazine A ()、DC1149B ()、麦角甾醇过氧化物 ()、神经酰胺 D/C ()、5-羟基-2,3-二甲基-7-甲氧基色酮 ()、Nafuredin A () 和 Harzianumols E/F ()。它们的结构通过各种光谱技术鉴定，并与文献中的结构进行了比较。值得注意的是，化合物和-是首次从该物种中报道的。对所有分离化合物的抗癌活性进行了评价。化合物、和-是对三种癌细胞系（人骨髓瘤 KMS-11、结肠直肠 HT-29 和胰腺 PANC-1）具有最活跃的增殖抑制活性的化合物。有趣的是，化合物在葡萄糖饥饿条件下对 PANC-1 癌细胞表现出抗饥饿活性，IC 为 22.43 μM，而化合物则没有。
