来自红树林真菌SCSIO 41433的新型聚酮化合物和丁烯内酯衍生物

New Polyketide and Butenolide Derivatives from the Mangrove Fungus SCSIO 41433.

作者信息

Xiao Zimin, Liang Jiaqi, Yang Chun, Cai Jian, Yang Bin, Zhou Xuefeng, Yuan Jie, Tao Huaming

机构信息

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.

Guangdong Key Laboratory of Marine Materia Medica/State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.

出版信息

Mar Drugs. 2025 Jun 13;23(6):251. doi: 10.3390/md23060251.

DOI:10.3390/md23060251

PMID:40559660

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12194153/

Abstract

Two new racemic mixtures, including a polyketide, (±)-penilactone F (), and a butenolide, (±) phenylbutyrolactone IIa (), were isolated from the mangrove sediment-derived strain SCSIO 41433. Additionally, 20 known compounds were isolated, including four penicillin-like compounds (-), three alkaloids (-), one sesquiterpene (), and four phenolic acids (-). Their structures were elucidated through NMR spectroscopy, HRESIMS, X-ray diffraction, and ECD calculations. In the PDE4 inhibitory activity and anticancer cell activity assays, compounds , , , , , -, and exhibited weak PDE4 inhibitory activity at a concentration of 10 µM, Compound demonstrated potent inhibitory effects against six cancer cell lines (MDA-MB-231, MDA-MB-435, HCT116, SNB-19, PC3, and A549), with IC values ranging from 3.4 to 23.7 µM.

摘要

从源自红树林沉积物的菌株SCSIO 41433中分离出两种新的外消旋混合物，包括一种聚酮化合物（±）-penilactone F（）和一种丁烯内酯（±）-phenylbutyrolactone IIa（）。此外，还分离出20种已知化合物，包括四种青霉素类化合物（-）、三种生物碱（-）、一种倍半萜（）和四种酚酸（-）。通过核磁共振光谱、高分辨电喷雾电离质谱、X射线衍射和电子圆二色计算对它们的结构进行了阐明。在磷酸二酯酶4（PDE4）抑制活性和抗癌细胞活性测定中，化合物、、、、、 - 和在10 μM浓度下表现出较弱的PDE4抑制活性，化合物对六种癌细胞系（MDA-MB-231、MDA-MB-435、HCT116、SNB-19、PC3和A549）表现出强效抑制作用，IC值范围为3.4至23.7 μM。