海洋来源真菌 BTBU20211089 的新次生代谢产物
New Secondary Metabolites from the Marine-Derived Fungus BTBU20211089.
机构信息
School of Light Industry, Beijing Technology and Business University, Beijing 100048, China.
School of Ocean Sciences, China University of Geosciences, Beijing 100083, China.
出版信息
Mar Drugs. 2022 Jan 18;20(2):79. doi: 10.3390/md20020079.
Seven new compounds, namely talaromanloid A (), talaromydene (), 10-hydroxy-8-demethyltalaromydine and 11-hydroxy-8-demethyltalaromydine ( and ), talaromylectone (), and ditalaromylectones A and B ( and ), together with seven known compounds were identified from a marine-derived fungus, BTBU20211089, which was isolated from a sediment sample collected from the South China Sea. Their chemical structures were determined using spectroscopic data, including HRESIMS, 1D, and 2D NMR techniques. The absolute configurations of and were elucidated by comparing experimental and calculated ECD spectra. Compounds , , and are new compounds possessing a novel carbon skeleton. Compound is a dimeric molecule of and . Compound shared a unique structure of the cyclized dimer of and . All the compounds were tested for their bioactivities against , , and .
从南海沉积物中分离得到的一株海洋真菌 BTBU20211089 中鉴定出了 7 种新化合物，分别为 talaromanloid A()、talaromydene()、10-羟基-8-去甲基talaromydine 和 11-羟基-8-去甲基talaromydine()、talaromylectone()和 ditalaromylectones A 和 B()，以及 7 种已知化合物。采用高分辨质谱、1D 和 2D NMR 等光谱数据确定了它们的化学结构。通过比较实验和计算的 ECD 光谱，阐明了和的绝对构型。和是具有新型骨架的新化合物。化合物是和的二聚体。化合物是和环化二聚体的独特结构。所有化合物均进行了对、和的生物活性测试。
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