氨基糖苷类抗生素与过滤材料的结合。
Binding of aminoglycoside antibiotics to filtration materials.
作者信息
Wagman G H, Bailey J V, Weinstein M J
出版信息
Antimicrob Agents Chemother. 1975 Mar;7(3):316-9. doi: 10.1128/AAC.7.3.316.
An investigation to study adsorption of gentamicin and other related aminoglycoside antibiotics to cellulose, diatomaceous earth (Celite), and Seitz filter sheets was carried out. Experiments with five aminoglycosides indicated that 30 to 100% of these antibiotics was adsorbed to cellulose depending on the ratio of antibiotic to adsorbent, and the total quantity could not be removed by acidification. Similarly, a study with gentamicin found adsorption to diatomaceous earth to be in the range of 33 to 98%. Neomycin and gentamicin were also readily adsorbed to Seitz filter sheets. The data indicate that large losses may occur during filtration of these antibiotics under certain conditions, and care should be taken to properly evaluate results during studies with these compounds in the presence of adsorbent materials.
开展了一项关于庆大霉素及其他相关氨基糖苷类抗生素对纤维素、硅藻土（助滤剂）和赛茨滤片吸附作用的研究。对五种氨基糖苷类药物进行的实验表明，取决于抗生素与吸附剂的比例，这些抗生素中有30%至100%会被纤维素吸附，并且通过酸化无法去除总量。同样，一项关于庆大霉素的研究发现其对硅藻土的吸附率在33%至98%范围内。新霉素和庆大霉素也很容易被赛茨滤片吸附。数据表明，在某些条件下过滤这些抗生素时可能会出现大量损失，在使用这些化合物并存在吸附材料的研究过程中，应谨慎妥善评估结果。
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