光果勾儿茶的细胞毒性成分。

Cytotoxic principles from Ventilago leiocarpa.

作者信息

Lin L C, Chou C J, Kuo Y C

机构信息

National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, Republic of China.

出版信息

J Nat Prod. 2001 May;64(5):674-6. doi: 10.1021/np000569d.

DOI:10.1021/np000569d

PMID:11374975

Abstract

Three new anthraquinones, islandicin 4-methyl ether (1), 1,2,6-trihydroxy-7,8-dimethoxy-3-methylanthraquinone (2), and 2-hydroxyemodin 1-methyl ether (3) as well as two known triterpenoids [taraxerol (4), lupeol (5)], six anthraquinones [chrysophanol (6), islandicin (8), parietin (9), emodin (10), catenarin (11), skyrin (15)], a 2,3-dihydroflavonol [(+)-aromadendrin (12)], two benzisochromanquinones [ventiloquinone K (13) and ventiloquinone I (14)], and stigmasterol (7) were isolated from Ventilago leiocarpa. The cytotoxicity of these compounds to various tumor cell lines was evaluated, and compound 15 significantly suppressed growth of HeLa, Vero, K562, Raji, Wish, and Calu-1 tumor cell lines. With the exception of K562 cells, the proliferation of other tumor cell lines was inhibited by compounds 3 and 10.

摘要

从光果风车子中分离出三种新的蒽醌类化合物，即异岛霉素4 - 甲醚（1）、1,2,6 - 三羟基 - 7,8 - 二甲氧基 - 3 - 甲基蒽醌（2）和2 - 羟基大黄素1 - 甲醚（3），以及两种已知的三萜类化合物[蒲公英赛醇（4）、羽扇豆醇（5）]、六种蒽醌类化合物[大黄酚（6）、异岛霉素（8）、紫铆因（9）、大黄素（10）、链状菌素（11）、天精（15）]、一种2,3 - 二氢黄酮醇[（+） - 香橙素（12）]、两种苯并异色满醌[ventiloquinone K（13）和ventiloquinone I（14）]和豆甾醇（7）。评估了这些化合物对各种肿瘤细胞系的细胞毒性，化合物15显著抑制了HeLa、Vero、K562、Raji、Wish和Calu - 1肿瘤细胞系的生长。除K562细胞外，化合物3和10抑制了其他肿瘤细胞系的增殖。