Li Yitong, Chen Yu, Xie Wenli, Li Xueni, Mei Gui, Xu Jing, Zhao Xiangpei, Teng Hongli, Yang Guangzhong
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
College of Chemistry and Material Sciences, South-Central University for Nationalities, Wuhan, China.
Front Chem. 2022 Apr 14;10:889441. doi: 10.3389/fchem.2022.889441. eCollection 2022.
Eight new phenolic compounds, named bercheminols A-H (), and eleven known analogues were isolated from the stems and leaves of (L.) DC. Their structures including the absolute configurations were elucidated by extensive spectroscopic analysis, chemical method, and quantum chemical calculations. Compound possesses an unprecedented 3,4-dihydro-11H-benzo[b]pyrano[4,3-e] oxepin-11-one skeleton. The other new compounds belong to three structural types of natural products, including naphthopyrones (), flavonoids (), and bibenzyl (). The -glucosidase inhibitory activities of the isolated compounds were assayed. As a result, vittarin-B (), rubrofusarin-6---D-glucopyranoside (), quercetin (), kaempferol (), and dihydrokaempferol () showed moderate inhibitory activities against -glucosidase with IC values of 22.5, 28.0, 36.5, 32.7, and 31.9 μM, respectively.
从毛钩藤（Uncaria hirsuta (Havil.) DC.）的茎和叶中分离出8个新的酚类化合物，命名为钩藤醇A-H（bercheminols A-H），以及11个已知类似物。通过广泛的光谱分析、化学方法和量子化学计算阐明了它们的结构，包括绝对构型。化合物1具有前所未有的3,4-二氢-11H-苯并[b]吡喃并[4,3-e]氧杂卓-11-酮骨架。其他新化合物属于三种天然产物结构类型，包括萘并吡喃酮类（naphthopyrones）、黄酮类（flavonoids）和联苄类（bibenzyl）。对分离得到的化合物进行了α-葡萄糖苷酶抑制活性测定。结果显示，钩藤碱B（vittarin-B）、红镰霉素-6-O-β-D-葡萄糖吡喃糖苷（rubrofusarin-6-O-β-D-glucopyranoside）、槲皮素（quercetin）、山柰酚（kaempferol）和二氢山柰酚（dihydrokaempferol）对α-葡萄糖苷酶表现出中等抑制活性，IC50值分别为22.5、28.0、36.5、32.7和31.9 μM。
