Leiter L A, Barr A, Bélanger A, Lubin S, Ross S A, Tildesley H D, Fontaine N
St. Michael's Hospital and University of Toronto, 61 Queen St. E., M4V 2L5 Toronto, Ontario, Canada.
Diabetes Care. 2001 Jun;24(6):1038-43. doi: 10.2337/diacare.24.6.1038.
To assess the prevalence of undiagnosed diabetes and glucose intolerance in individuals > or =40 years of age who contacted their family physician for routine care.
The study used a stratified randomized selection of family physicians across Canada that was proportional to provincial and urban/rural populations based on Statistics Canada Census data (1996). Consecutive patients > or =40 years of age were screened for diabetes. If a casual fingerprick blood glucose was >5.5 mmol/l, the patient returned for a fasting venous blood glucose test. If the fasting blood glucose was 6.1-6.9 mmol/l, a 2-h 75-g post-glucose load venous blood glucose was obtained. Results of these tests were used to classify patients in diagnostic categories.
Data were available for 9,042 patients. Previously undiagnosed diabetes was discovered in 2.2% of the patients, and new glucose intolerance was found in an additional 3.5% of patients. Overall, 16.4% of patients had previously known diabetes. The decrease in fasting plasma glucose criterion from 7.8 to 7.0 mmol/l resulted in a 2.2% versus a 1.6% prevalence of new diabetes. Several risk factors were reported in a significantly greater proportion of patients with new glucose intolerance and either new and known diabetes compared with the normal glucose tolerance group of patients.
Routine screening for diabetes by family physicians is justified in patients > or =40 years of age, given the finding of previously undiagnosed diabetes in 2.2% of these patients and newly diagnosed glucose intolerance in an additional 3.5% of these patients. Another 16.4% of primary care patients > or =40 years of age have known diabetes. This has important implications regarding health resources and physician education.
评估年龄≥40岁因接受常规医疗服务而联系家庭医生的个体中未诊断糖尿病和糖耐量异常的患病率。
本研究采用分层随机抽样法,根据加拿大统计局1996年人口普查数据,按省份及城乡人口比例在全国范围内选取家庭医生。对年龄≥40岁的连续就诊患者进行糖尿病筛查。若随机指尖血糖>5.5 mmol/L,则患者需返回进行空腹静脉血糖检测。若空腹血糖为6.1 - 6.9 mmol/L,则进行葡萄糖负荷后2小时静脉血糖检测。这些检测结果用于将患者分类至不同诊断类别。
共获得9042例患者的数据。在2.2%的患者中发现了之前未诊断的糖尿病,另有3.5%的患者发现了新的糖耐量异常。总体而言,16.4%的患者之前已确诊糖尿病。空腹血糖诊断标准从7.8 mmol/L降至7.0 mmol/L,导致新诊断糖尿病的患病率从2.2%变为1.6%。与糖耐量正常组患者相比,新的糖耐量异常患者以及新诊断和已知糖尿病患者中,有几种危险因素的报告比例显著更高。
鉴于在年龄≥40岁的患者中,2.2%的患者发现了之前未诊断的糖尿病,另有3.5%的患者发现了新诊断的糖耐量异常,家庭医生对年龄≥40岁的患者进行糖尿病常规筛查是合理的。另有16.4%年龄≥40岁的初级保健患者已确诊糖尿病。这对卫生资源和医生教育具有重要意义。