Mantovani A, Locati M, Vecchi A, Sozzani S, Allavena P
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157, Milan, Italy.
Trends Immunol. 2001 Jun;22(6):328-36. doi: 10.1016/s1471-4906(01)01941-x.
The canonical concept of a receptor includes specific ligand recognition, usually with high affinity and specificity, and signaling. Decoy receptors recognize certain inflammatory cytokines with high affinity and specificity, but are structurally incapable of signaling or presenting the agonist to signaling receptor complexes. They act as a molecular trap for the agonist and for signaling receptor components. The interleukin-1 type II receptor (IL-1RII) was the first pure decoy to be identified. Decoy receptors have subsequently been identified for members of the tumor necrosis factor receptor and IL-1R families. Moreover, silent nonsignaling receptors could act as decoys for chemokines. Therefore, the use of decoy receptors is a general strategy to regulate the action of primary pro-inflammatory cytokines and chemokines.
受体的经典概念包括特异性配体识别，通常具有高亲和力和特异性，以及信号传导。诱饵受体以高亲和力和特异性识别某些炎性细胞因子，但在结构上无法进行信号传导或向信号受体复合物呈递激动剂。它们充当激动剂和信号受体组分的分子陷阱。白细胞介素-1Ⅱ型受体（IL-1RII）是首个被鉴定出的纯诱饵受体。随后，在肿瘤坏死因子受体和IL-1R家族成员中也鉴定出了诱饵受体。此外，沉默的无信号传导受体可充当趋化因子的诱饵。因此，使用诱饵受体是调节主要促炎细胞因子和趋化因子作用的一种通用策略。
