细胞因子诱饵受体和清道夫受体作为免疫和炎症的关键调节因子。
Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation.
作者信息
Bonecchi Raffaella, Garlanda Cecilia, Mantovani Alberto, Riva Federica
机构信息
Istituto Clinico Humanitas IRCCS, via Manzoni 113, 20089 Rozzano, Italy; Humanitas University, via Manzoni 113, 20089 Rozzano, Italy.
Istituto Clinico Humanitas IRCCS, via Manzoni 113, 20089 Rozzano, Italy.
出版信息
Cytokine. 2016 Nov;87:37-45. doi: 10.1016/j.cyto.2016.06.023. Epub 2016 Aug 4.
Abstract
IL-1R2 was the first decoy receptor to be described. Subsequently receptors which act as pure decoys or scavengers or trigger dampening of cytokine signaling have been described for cytokines and chemokines. Here we review the current understanding of the mode of action and significance in pathology of the chemokine atypical receptor ACKR2, the IL-1 decoy receptor IL-1R2 and the atypical IL-1 receptor family IL-1R8. Decoy and scavenger receptors with no or atypical signaling have emerged as a general strategy conserved in evolution to tune the action of cytokines, chemokines and growth factors.
摘要
IL-1R2是首个被描述的诱饵受体。随后，针对细胞因子和趋化因子，已描述了作为纯诱饵或清除剂或触发细胞因子信号传导减弱的受体。在此，我们综述了目前对趋化因子非典型受体ACKR2、IL-1诱饵受体IL-1R2和非典型IL-1受体家族IL-1R8的作用模式及其在病理学中意义的理解。不具有信号传导或具有非典型信号传导的诱饵和清除受体已成为进化中保守的一种通用策略，用于调节细胞因子、趋化因子和生长因子的作用。
相似文献
1
Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation.细胞因子诱饵受体和清道夫受体作为免疫和炎症的关键调节因子。
Cytokine. 2016 Nov;87:37-45. doi: 10.1016/j.cyto.2016.06.023. Epub 2016 Aug 4.
2
Tuning of innate immunity and polarized responses by decoy receptors.诱饵受体对固有免疫和极化反应的调节
Int Arch Allergy Immunol. 2003 Oct;132(2):109-15. doi: 10.1159/000073711.
3
Regulatory pathways in inflammation.炎症中的调节通路。
Autoimmun Rev. 2007 Nov;7(1):8-11. doi: 10.1016/j.autrev.2007.03.002. Epub 2007 Mar 26.
4
Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease.白细胞介素-1 系统的负调控：白细胞介素-1R2 和白细胞介素-1R8 的作用及其在病理生理学和疾病中的相关性。
Front Immunol. 2022 Feb 8;13:804641. doi: 10.3389/fimmu.2022.804641. eCollection 2022.
5
Negative regulatory receptors of the IL-1 family.白细胞介素-1 家族的负调控受体。
Semin Immunol. 2013 Dec 15;25(6):408-15. doi: 10.1016/j.smim.2013.10.019. Epub 2013 Nov 14.
6
Wandering pathways in the regulation of innate immunity and inflammation.固有免疫和炎症调节中的游走通路。
J Autoimmun. 2017 Dec;85:1-5. doi: 10.1016/j.jaut.2017.10.007. Epub 2017 Oct 25.
7
Tuning inflammation and immunity by chemokine sequestration: decoys and more.通过趋化因子隔离调节炎症和免疫：诱饵及其他方法
Nat Rev Immunol. 2006 Dec;6(12):907-18. doi: 10.1038/nri1964.
8
Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines.诱饵受体：一种调节炎性细胞因子和趋化因子的策略。
Trends Immunol. 2001 Jun;22(6):328-36. doi: 10.1016/s1471-4906(01)01941-x.
9
Extracellular and intracellular decoys in the tuning of inflammatory cytokines and Toll-like receptors: the new entry TIR8/SIGIRR.细胞外和细胞内诱饵对炎性细胞因子和Toll样受体的调节作用：新成员TIR8/SIGIRR
J Leukoc Biol. 2004 May;75(5):738-42. doi: 10.1189/jlb.1003473. Epub 2003 Dec 12.
10
Novel pathways for negative regulation of inflammatory cytokines centered on receptor expression.以受体表达为中心的炎症细胞因子负调控新途径。
Dev Biol Stand. 1999;97:97-104.
引用本文的文献
1
Antagonizing Il10 and Il4 signaling via intracerebral decoy receptor expression attenuates Aβ accumulation.通过脑内诱饵受体表达拮抗白细胞介素10（Il10）和白细胞介素4（Il4）信号传导可减轻β淀粉样蛋白（Aβ）的积累。
Acta Neuropathol Commun. 2025 Mar 7;13(1):51. doi: 10.1186/s40478-025-01968-3.
2
IL-1β in Neoplastic Disease and the Role of Its Tumor-Derived Form in the Progression and Treatment of Metastatic Prostate Cancer.肿瘤性疾病中的白细胞介素-1β及其肿瘤衍生形式在转移性前列腺癌进展和治疗中的作用。
Cancers (Basel). 2025 Jan 17;17(2):290. doi: 10.3390/cancers17020290.
3
Selective expression and significance of ACKR2 in lung aerocytes.趋化因子受体2在肺上皮细胞中的选择性表达及其意义
J Immunother Cancer. 2025 Jan 21;13(1):e009467. doi: 10.1136/jitc-2024-009467.
4
Chemokines Signature and T Cell Dynamics in Leishmaniasis: Molecular insight and therapeutic application.利什曼病中的趋化因子特征与T细胞动态：分子洞察与治疗应用
Expert Rev Mol Med. 2024 Nov 26;27:1-55. doi: 10.1017/erm.2024.36.
5
B7H4 Role in Solid Cancers: A Review of the Literature.B7H4在实体癌中的作用：文献综述
Cancers (Basel). 2024 Jul 11;16(14):2519. doi: 10.3390/cancers16142519.
6
The temporal progression of lung immune remodeling during breast cancer metastasis.乳腺癌转移过程中肺部免疫重构的时间进程。
Cancer Cell. 2024 Jun 10;42(6):1018-1031.e6. doi: 10.1016/j.ccell.2024.05.004. Epub 2024 May 30.
7
A mathematical modeling technique to understand the role of decoy receptors in ligand-receptor interaction.一种用于理解诱饵受体在配体-受体相互作用中作用的数学建模技术。
Sci Rep. 2023 Apr 21;13(1):6523. doi: 10.1038/s41598-023-33596-z.
8
Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.研究表明，中和抗体介导的中性粒细胞激活与 C-C 基序趋化因子受体样 2（CCRL2）配体结合功能无关。
PLoS One. 2023 Jan 20;18(1):e0280590. doi: 10.1371/journal.pone.0280590. eCollection 2023.
9
The DARC Side of Inflamm-Aging: Duffy Antigen Receptor for Chemokines (DARC/ACKR1) as a Potential Biomarker of Aging, Immunosenescence, and Breast Oncogenesis among High-Risk Subpopulations.炎症衰老的 DARC 方面：趋化因子 Duffy 抗原受体 (DARC/ACKR1) 作为高危亚人群衰老、免疫衰老和乳腺癌发生的潜在生物标志物。
Cells. 2022 Nov 29;11(23):3818. doi: 10.3390/cells11233818.
10
Bps polysaccharide of Bordetella pertussis resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts Escherichia coli into a respiratory pathogen.百日咳博德特氏菌的 Bps 多糖通过充当双重表面盾牌和诱饵，并将大肠杆菌转化为呼吸道病原体，从而抵抗抗菌肽。
PLoS Pathog. 2022 Aug 15;18(8):e1010764. doi: 10.1371/journal.ppat.1010764. eCollection 2022 Aug.
本文引用的文献
1
Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice.通过基因敲除糖尿病OVE小鼠中的非典型趋化因子受体ACKR2实现肾脏保护
J Diabetes Res. 2016;2016:5362506. doi: 10.1155/2016/5362506. Epub 2015 Dec 20.
2
Epithelial IL-1R2 acts as a homeostatic regulator during remission of ulcerative colitis.上皮白细胞介素-1受体2在溃疡性结肠炎缓解期作为一种稳态调节因子发挥作用。
Mucosal Immunol. 2016 Jul;9(4):950-9. doi: 10.1038/mi.2015.108. Epub 2015 Nov 4.
3
Placental expression of D6 decoy receptor in preeclampsia.子痫前期中D6诱饵受体的胎盘表达。
Obstet Gynecol Sci. 2015 Sep;58(5):333-9. doi: 10.5468/ogs.2015.58.5.333. Epub 2015 Sep 22.
4
Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice.人结肠肿瘤表达一种显性负性形式的 SIGIRR，促进小鼠炎症和结肠炎相关的结肠癌。
Gastroenterology. 2015 Dec;149(7):1860-1871.e8. doi: 10.1053/j.gastro.2015.08.051. Epub 2015 Sep 5.
5
A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway.Toll样受体介导的炎症信号通路负调控的结构视角
Biophys J. 2015 Sep 15;109(6):1214-26. doi: 10.1016/j.bpj.2015.06.048. Epub 2015 Aug 11.
6
Microarray analysis identifies IL-1 receptor type 2 as a novel candidate biomarker in patients with acute respiratory distress syndrome.微阵列分析确定2型白细胞介素-1受体是急性呼吸窘迫综合征患者的一种新型候选生物标志物。
Respir Res. 2015 Feb 21;16(1):29. doi: 10.1186/s12931-015-0190-x.
7
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.IL-37 通过先天信号转导发挥其多方面抗炎作用，需要受体 IL-18Rα 和 IL-1R8（SIGIRR）来实现。
Nat Immunol. 2015 Apr;16(4):354-65. doi: 10.1038/ni.3103. Epub 2015 Mar 2.
8
IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.白细胞介素-1受体2型通过抑制巨噬细胞上的白细胞介素-1信号来抑制胶原诱导的关节炎。
J Immunol. 2015 Apr 1;194(7):3156-68. doi: 10.4049/jimmunol.1402155. Epub 2015 Feb 27.
9
Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8.白细胞介素-37的细胞外形式在体外和体内均可抑制先天性炎症，但需要白细胞介素-1家族诱饵受体白细胞介素-1受体8。
Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2497-502. doi: 10.1073/pnas.1424626112. Epub 2015 Feb 5.
10
α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.α-TLR2 抗体通过增强 SIGIRR 的表达来减弱小胶质细胞中 Aβ 介导的炎症反应。
Brain Behav Immun. 2015 May;46:70-9. doi: 10.1016/j.bbi.2015.01.005. Epub 2015 Jan 22.
Zotero 插件