南非I型糖尿病黑人中的人类白细胞抗原II类抗原

HLA class II antigens in South African Blacks with type I diabetes.

作者信息

Pirie F J, Hammond M G, Motala A A, Omar M A

机构信息

Department of Medicine, University of Natal, Congella, South Africa.

出版信息

Tissue Antigens. 2001 Apr;57(4):348-52. doi: 10.1034/j.1399-0039.2001.057004348.x.

DOI:10.1034/j.1399-0039.2001.057004348.x

PMID:11380945

Abstract

Type 1 diabetes mellitus is poorly characterised in many African communities, including South Africa, where little is known of the disease epidemiology. This study aimed to identify the HLA class II alleles associated with type 1 diabetes in a group of Zulu subjects in Durban, KwaZulu-Natal by PCR-SSP. The HLA alleles associated with type 1 diabetes included HLA-DQB0302 (P<0.0001), DRB1O9 (P<0.0001), DRB104 (P=0.002), DRB10301 (P=0.003), DQB02 (P=0.004) and DQA03 (P=0.035). Estimated haplotypes positively associated with type 1 diabetes included HLA-DRB1 0301-DQA0501, DRB104-DQA03, DRB104-DQB0302, DRB10301-DQB0201, DQA0501-DQB0201 and DQA03-DQB0302. These findings are similar to those reported from Zimbabwe and other populations with type 1 diabetes.

摘要

在包括南非在内的许多非洲社区，1型糖尿病的特征尚不明确，人们对该疾病的流行病学知之甚少。本研究旨在通过聚合酶链反应-序列特异性引物法（PCR-SSP），确定夸祖鲁-纳塔尔省德班市一组祖鲁族受试者中与1型糖尿病相关的人类白细胞抗原（HLA）Ⅱ类等位基因。与1型糖尿病相关的HLA等位基因包括HLA-DQB0302（P<0.0001）、DRB1O9（P<0.0001）、DRB104（P=0.002）、DRB10301（P=0.003）、DQB02（P=0.004）和DQA03（P=0.035）。与1型糖尿病呈正相关的估计单倍型包括HLA-DRB1 0301-DQA0501、DRB104-DQA03、DRB104-DQB0302、DRB10301-DQB0201、DQA0501-DQB0201和DQA03-DQB0302。这些发现与津巴布韦和其他1型糖尿病患者群体报告的结果相似。