预防非甾体抗炎药的胃肠道并发症。危险因素、最新进展及最新策略。
Preventing gastrointestinal complications of NSAIDs. Risk factors, recent advances, and latest strategies.
作者信息
Graumlich J F
机构信息
Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine, PO Box 1649, Peoria, IL 61656-1649, USA.
出版信息
Postgrad Med. 2001 May;109(5):117-20, 123-8. doi: 10.3810/pgm.2001.05.931.
In the United States, gastrointestinal complications induced by nonsteroidal anti-inflammatory drugs (NSAIDs) cause more than 100,000 hospitalizations and an estimated 16,500 deaths annually. Because serious gastrointestinal events can occur without warning, prevention measures must not rely on warning signs alone. This article discusses the epidemiology of NSAID-induced toxic episodes, reviews the risk factors for these occurrences, and offers strategies for minimizing the risk among long-term NSAID users.
在美国，非甾体抗炎药（NSAIDs）引发的胃肠道并发症每年导致超过10万例住院治疗，估计有16,500人死亡。由于严重的胃肠道事件可能毫无征兆地发生，预防措施绝不能仅依赖警示信号。本文讨论了NSAIDs引起的中毒事件的流行病学，回顾了这些事件的风险因素，并为降低长期NSAIDs使用者的风险提供了策略。
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