Napolitano A, Salvetti S, Vista M, Lombardi V, Siciliano G, Giraldi C
Division of Neurology, Campo di Marte Hospital, I-55100 Lucca, Italy.
Neurol Sci. 2000;21(5 Suppl):S981-2. doi: 10.1007/s100720070015.
We report a patient with MELAS treated for 24 months with idebenone and riboflavin, during which no stroke-like episodes occurred. Moreover neurological symptoms clearly improved, and a recovery of brain MRI and EEG abnormalities was observed. We conclude that the combined treatment with idebenone and riboflavin may restore the metabolic impairment in MELAS, possibly improving the long-term prognosis in these patients.