• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Long-term treatment with idebenone and riboflavin in a patient with MELAS.

作者信息

Napolitano A, Salvetti S, Vista M, Lombardi V, Siciliano G, Giraldi C

机构信息

Division of Neurology, Campo di Marte Hospital, I-55100 Lucca, Italy.

出版信息

Neurol Sci. 2000;21(5 Suppl):S981-2. doi: 10.1007/s100720070015.

DOI:10.1007/s100720070015
PMID:11382201
Abstract

We report a patient with MELAS treated for 24 months with idebenone and riboflavin, during which no stroke-like episodes occurred. Moreover neurological symptoms clearly improved, and a recovery of brain MRI and EEG abnormalities was observed. We conclude that the combined treatment with idebenone and riboflavin may restore the metabolic impairment in MELAS, possibly improving the long-term prognosis in these patients.

摘要

相似文献

1
Long-term treatment with idebenone and riboflavin in a patient with MELAS.
Neurol Sci. 2000;21(5 Suppl):S981-2. doi: 10.1007/s100720070015.
2
Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS.
Neurology. 1996 Aug;47(2):583-5. doi: 10.1212/wnl.47.2.583.
3
Effect of long-term oral treatment with L-arginine and idebenone on the prevention of stroke-like episodes in an adult MELAS patient.长期口服精氨酸和艾地苯醌对成年 MELAS 患者卒中样发作的预防作用。
Rev Neurol (Paris). 2011 Nov;167(11):852-5. doi: 10.1016/j.neurol.2011.02.038. Epub 2011 Apr 22.
4
Regression of stroke-like lesions in MELAS-syndrome after seizure control.癫痫控制后 MELAS 综合征中风样病灶的消退。
Epileptic Disord. 2010 Dec;12(4):330-4. doi: 10.1684/epd.2010.0338. Epub 2010 Nov 9.
5
Beneficial effect of L-arginine for stroke-like episode in MELAS.L-精氨酸对线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)患者卒中样发作的有益作用。
Brain Dev. 2004 Oct;26(7):481-3; discussion 480. doi: 10.1016/j.braindev.2004.01.006.
6
Cerebral hyperemia in MELAS.线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)中的脑充血
Stroke. 1994 Sep;25(9):1873-6. doi: 10.1161/01.str.25.9.1873.
7
MR OEF imaging in MELAS.线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)中的磁共振波谱成像(MRS)脑氧提取分数(OEF)成像
Methods Enzymol. 2014;547:433-44. doi: 10.1016/B978-0-12-801415-8.00021-7.
8
L-arginine is effective in stroke-like episodes of MELAS associated with the G13513A mutation.L-精氨酸对与G13513A突变相关的MELAS的中风样发作有效。
Brain Dev. 2011 Jun;33(6):518-20. doi: 10.1016/j.braindev.2010.07.013. Epub 2010 Sep 15.
9
Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome.线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)综合征中风样发作时的神经元过度兴奋。
Neurology. 2002 Sep 24;59(6):816-24. doi: 10.1212/wnl.59.6.816.
10
Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10.天然产物与药物的界限:相关苯醌艾地苯醌和辅酶Q10的比较
Redox Biol. 2015;4:289-95. doi: 10.1016/j.redox.2015.01.009. Epub 2015 Jan 14.

引用本文的文献

1
Advances in mt-tRNA Mutation-Caused Mitochondrial Disease Modeling: Patients' Brain in a Dish.线粒体tRNA突变所致线粒体疾病模型的进展:盘中的患者大脑
Front Genet. 2021 Jan 12;11:610764. doi: 10.3389/fgene.2020.610764. eCollection 2020.
2
Riboflavin Deficiency-Implications for General Human Health and Inborn Errors of Metabolism.核黄素缺乏症——对人类整体健康和先天性代谢错误的影响。
Int J Mol Sci. 2020 May 28;21(11):3847. doi: 10.3390/ijms21113847.
3
Multisystem mitochondrial diseases due to mutations in mtDNA-encoded subunits of complex I.
多种系统线粒体疾病是由于 mtDNA 编码的复合物 I 亚单位突变引起的。
BMC Pediatr. 2020 Jan 29;20(1):41. doi: 10.1186/s12887-020-1912-x.
4
Pulmonary hypertension as a manifestation of mitochondrial disease: A case report and review of the literature.肺动脉高压作为线粒体疾病的一种表现:一例病例报告及文献综述
Medicine (Baltimore). 2017 Nov;96(46):e8716. doi: 10.1097/MD.0000000000008716.
5
Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson's Disease.氧化应激:对遗传性线粒体疾病和帕金森病的机制性见解
J Clin Med. 2017 Oct 27;6(11):100. doi: 10.3390/jcm6110100.
6
Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner.艾地苯醌以发育阶段依赖性方式调节人诱导多能干细胞的线粒体生物合成和神经分化。
Biogerontology. 2017 Aug;18(4):665-677. doi: 10.1007/s10522-017-9718-4. Epub 2017 Jun 22.
7
Mitochondrial disease patients' perception of dietary supplements' use.线粒体疾病患者对膳食补充剂使用的认知
Mol Genet Metab. 2016 Sep;119(1-2):100-8. doi: 10.1016/j.ymgme.2016.07.005. Epub 2016 Jul 16.
8
Nutrition Therapy for Mitochondrial Neurogastrointestinal Encephalopathy with Homozygous Mutation of the TYMP Gene.TYMP基因纯合突变所致线粒体神经胃肠性脑肌病的营养治疗
Clin Nutr Res. 2015 Apr;4(2):132-6. doi: 10.7762/cnr.2015.4.2.132. Epub 2015 Jan 16.
9
Mitochondrial respiration without ubiquinone biosynthesis.线粒体呼吸而不进行泛醌生物合成。
Hum Mol Genet. 2013 Dec 1;22(23):4768-83. doi: 10.1093/hmg/ddt330. Epub 2013 Jul 11.
10
How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs.线粒体功能障碍如何影响斑马鱼发育和心血管功能:一种用于测试线粒体靶向药物的体内模型。
Br J Pharmacol. 2013 Jul;169(5):1072-90. doi: 10.1111/bph.12186.