图阿雷格人群的HL-A基因结构。II. 凯尔迪尼格人

The HL-A gene structure of Twareg populations. II. The Kel Dinig.

作者信息

Colombani J, Chaventre A, Jacquard A, Degos L, Leferre-Wittier P, Solal C, Dastot H, Reboul M, Csaszar E

出版信息

Tissue Antigens. 1975 Feb;5(1):3-11. doi: 10.1111/j.1399-0039.1975.tb00519.x.

DOI:10.1111/j.1399-0039.1975.tb00519.x

Abstract

The HL-A groups of 138 Kel Diniq Twaregs were determined by the platelet complement fixation microtechnique. Their HL-A characteristics, compared to those of Caucasoid populations, are: decrease in HL-A2, 9, W17 and W15; increase in W28, W32, HL-A7, W5, W10 and second locus blank; absence of Da25 (W30 plus W31), HL-A13, W15, W18, W27. This genetic structure is in accordance with the isolated condition of this population. The most frequent haplotypes are W28,HL-A7, common to both the Kel Diniq and the Kel Kummer Twaregs previously studied; W32,W10 and HL-A3, HL-A5, Kel Diniq only. These two populations are both isolates, with a common origin the seventeenth century, but separated as from that date. Genealogical studies have enabled the haplotype W28,HL-A7 to be attributed to the two brothers who founded the populations in the seventeenth century. A comparison of these two populations constitutes a model for the study of genetic drift and the founder effect.

摘要

采用血小板补体结合微量技术对138名凯尔迪尼克图阿雷格人的HL-A血型组进行了测定。与高加索人群相比，他们的HL-A特征如下：HL-A2、9、W17和W15减少；W28、W32、HL-A7、W5、W10增加，第二位点空白；不存在Da25（W30加W31）、HL-A13、W15、W18、W27。这种基因结构与该人群的隔离状况相符。最常见的单倍型是W28、HL-A7，凯尔迪尼克人和先前研究过的凯尔库默图阿雷格人都有；W32、W10以及HL-A3、HL-A5，仅凯尔迪尼克人有。这两个人群都是隔离群体，起源于17世纪，但自那时起就分开了。系谱研究已将单倍型W28、HL-A7归因于17世纪创建这些人群的两兄弟。对这两个人群的比较构成了研究基因漂变和奠基者效应的模型。