Layrisse Z, Rodríguez M P, Rodrguez-Iturbe B, García E, Stoikow Z, Salas G
Vox Sang. 1976;31(1):37-47. doi: 10.1111/j.1423-0410.1976.tb02857.x.
HL-A antigen and gene frequencies of 206 unrelated adults living in the cities of Caracas and Maracaibo have shown that this heterogeneous Venezuelan population sample possess 11 specificities of the first (LA) HL-A series and 15 specificities of the second (Four) series. HL-A2, HL-A9, HL-A5 and W5 showed frequencies higher than those observed in caucasoid populations. The most frequent haplotypes were 2, W5; 2, 5; 9, 12; 2, 12 and 2, X2. No outstandingly high value for gametic association between the alleles of the 2 HL-A series was observed, but haplotypes formed by antigens with dissimilar frequencies in Caucasoids, Negroids and American Indian tribes have shown statistically significant D values. Genetic distance calculated using the HL-A system alone showed that this population is closer to the average Caucasoid and Negroid population tested at the 5th International Histocompatibility Workshop than to 2 American Indian tribes living in the same country.
对居住在加拉加斯和马拉开波市的206名无亲缘关系成年人的HL-A抗原和基因频率研究表明，这个具有异质性的委内瑞拉人群样本拥有第一（LA）HL-A系列的11种特异性和第二（Four）系列的15种特异性。HL-A2、HL-A9、HL-A5和W5的频率高于在高加索人群中观察到的频率。最常见的单倍型是2，W5；2，5；9，12；2，12和2，X2。未观察到两个HL-A系列等位基因之间的配子关联有特别高的值，但由在高加索人、黑人及美洲印第安部落中频率不同的抗原形成的单倍型显示出具有统计学意义的D值。仅使用HL-A系统计算的遗传距离表明，该人群与在第五届国际组织相容性研讨会上测试的平均高加索人和黑人人群相比，比与生活在同一国家的两个美洲印第安部落更为接近。
