Fulhorst C F, Charrel R N, Weaver S C, Ksiazek T G, Bradley R D, Milazzo M L, Tesh R B, Bowen M D
University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.
Emerg Infect Dis. 2001 May-Jun;7(3):403-7. doi: 10.3201/eid0703.010306.
The purpose of this study was to extend our knowledge of the geographic distribution and genetic diversity of the arenavirus(es) associated with Neotoma species (woodrats) in the southwestern United States. Infectious arenavirus was recovered from 14 (3.3%) of 425 woodrats. The virus-positive species included N. albigula in New Mexico and Oklahoma, N. cinerea in Utah, N. mexicana in New Mexico and Utah, and N. micropus in Texas. Analyses of viral nucleocapsid protein gene sequence data indicated that all the isolates were strains of the Whitewater Arroyo virus, an arenavirus previously known only from northwestern New Mexico. Analyses of the sequence data also indicated that there can be substantial genetic diversity among strains of Whitewater Arroyo virus from conspecific woodrats collected from different localities and substantial genetic diversity among strains from different woodrat species collected from the same locality.
本研究的目的是拓展我们对美国西南部与林鼠属（林鼠）相关的沙粒病毒地理分布和遗传多样性的认识。从425只林鼠中的14只（3.3%）体内分离出了具有传染性的沙粒病毒。病毒呈阳性的物种包括新墨西哥州和俄克拉荷马州的白喉林鼠、犹他州的灰林鼠、新墨西哥州和犹他州的墨西哥林鼠以及得克萨斯州的小林鼠。对病毒核衣壳蛋白基因序列数据的分析表明，所有分离株均为白水阿罗约病毒的毒株，该沙粒病毒此前仅在新墨西哥州西北部被发现。序列数据分析还表明，从不同地点采集的同种林鼠所携带的白水阿罗约病毒毒株之间可能存在显著的遗传多样性，且从同一地点采集的不同林鼠物种所携带的毒株之间也存在显著的遗传多样性。
