Kosoy M Y, Elliott L H, Ksiazek T G, Fulhorst C F, Rollin P E, Childs J E, Mills J N, Maupin G O, Peters C J
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Am J Trop Med Hyg. 1996 Jun;54(6):570-6. doi: 10.4269/ajtmh.1996.54.570.
The objectives of this study were to extend our knowledge of the geographic distribution and rodent host range of arenaviruses in North America. Sera from wild rodents collected from the southern and western United States were tested for antibody against Tamiami, Pichinde, Junin, and lymphocytic choriomeningitis viruses, using an indirect fluorescent antibody test. Antibody to at least one arenavirus was found in 220 (3.1%) of 7,106 rodents tested. The antibody-positive animals included Mus musculus from Florida and Texas; Neotoma albigula from Arizona, Colorado, and New Mexico; N. fuscipes and N. lepida from California: N. mexicana from Arizona, New Mexico, and Utah; N. stephensi from Arizona and New Mexico; and Oryzomys palustris and Sigmodon hispidus from Florida. Sigmodon hispidus seropositive for Tamiami virus were found only in Florida (156 [27.0%] of 578 tested), although 463 hispid cotton rats from outside that state were examined. High-titered antibodies to Tamiami virus were present in sera from S. hispidus, (geometric mean antibody titer [GMAT] of 1:792), whereas sera from Neotoma spp. reacted at high titer to both Tamiami (GMAT = 1:905) and Pichinde (GMAT = 1:433) viruses. The results suggest that arenaviruses are widely distributed in the southern United States and that one or more indigenous arenaviruses are associated with Neotoma spp. in North America.
本研究的目的是拓展我们对北美洲沙粒病毒地理分布和啮齿动物宿主范围的认识。使用间接荧光抗体试验，对从美国南部和西部采集的野生啮齿动物的血清进行检测，以检测其针对塔米亚米病毒、皮钦德病毒、胡宁病毒和淋巴细胞性脉络丛脑膜炎病毒的抗体。在检测的7106只啮齿动物中，有220只（3.1%）检测到针对至少一种沙粒病毒的抗体。抗体呈阳性的动物包括来自佛罗里达州和得克萨斯州的小家鼠；来自亚利桑那州、科罗拉多州和新墨西哥州的白喉林鼠；来自加利福尼亚州的棕林鼠和浅色林鼠；来自亚利桑那州、新墨西哥州和犹他州的墨西哥林鼠；来自亚利桑那州和新墨西哥州的斯蒂芬斯林鼠；以及来自佛罗里达州的稻鼠和刚毛棉鼠。仅在佛罗里达州发现了对塔米亚米病毒血清呈阳性的刚毛棉鼠（在检测的578只中，有156只[27.0%]），尽管对该州以外的463只刚毛棉鼠进行了检测。刚毛棉鼠的血清中存在高滴度的抗塔米亚米病毒抗体（几何平均抗体滴度[GMAT]为1:792），而林鼠属动物的血清对塔米亚米病毒（GMAT = 1:905）和皮钦德病毒（GMAT = 1:433）均有高滴度反应。结果表明，沙粒病毒在美国南部广泛分布，并且在北美洲有一种或多种本土沙粒病毒与林鼠属动物有关。
