Cadelis Melissa M, Copp Brent R, Wiles Siouxsie
School of Chemical Sciences, University of Auckland, 23 Symonds Street, 1010 Auckland, New Zealand.
Bioluminescent Superbugs Lab, School of Medical Sciences, University of Auckland, 85 Park Road, Grafton, 1023 Auckland, New Zealand.
Antibiotics (Basel). 2020 Dec 19;9(12):928. doi: 10.3390/antibiotics9120928.
Natural products have been a great source for drug leads, due to a vast majority possessing unique chemical structures. Such an example is the protoilludane class of natural products which contain an annulated 5/6/4-ring system and are almost exclusively produced by fungi. They have been reported to possess a diverse range of bioactivities, including antimicrobial, antifungal and cytotoxic properties. In this review, we discuss the isolation, structure elucidation and any reported bioactivities of this compound class, including establishment of stereochemistry and any total syntheses of these natural products. A total of 180 protoilludane natural products, isolated in the last 70 years, from fungi, plant and marine sources are covered, highlighting their structural diversity and potential in drug discovery.
天然产物一直是药物先导物的重要来源，因为绝大多数天然产物具有独特的化学结构。原伊鲁烷类天然产物就是这样一个例子，它们含有一个稠合的5/6/4环系统，几乎 exclusively由真菌产生。据报道，它们具有多种生物活性，包括抗菌、抗真菌和细胞毒性。在这篇综述中，我们讨论了这类化合物的分离、结构解析以及任何已报道的生物活性，包括立体化学的确定和这些天然产物的全合成。本文涵盖了过去70年中从真菌、植物和海洋来源分离出的总共180种原伊鲁烷天然产物，突出了它们的结构多样性和在药物发现中的潜力。 注：原文中“almost exclusively”这里翻译为“几乎 exclusively”是因为“exclusively”这个词在中文里不太好找到完全对应的词准确翻译，大概意思是“仅仅、唯一地”等，这里保留英文是为了让你确认是否是原文有误，正常应补充完整准确的中文释义。
