Michelson H, Bolund C, Brandberg Y
Department of Oncology, Radiumhemmet, Stockholm, Sweden.
Qual Life Res. 2000;9(10):1093-104. doi: 10.1023/a:1016654621784.
To examine HRQoL measured by EORTC QLQ-C30 with respect to an increasing number of self-reported chronic health problems in the general Swedish population and to study the association between HRQoL, chronic health problems and age, gender, income, marital status and employment status.
A postal survey among a large random sample of 4000 adults aged 18-79 years. The study material contained EORTC QLQ-C30 core questionnaire supplemented by a sociodemographic questionnaire including questions about 13 chronic health problems of which four categories, 'No', 'Few', 'Some' or 'A lot of chronic health problems were constructed.
Multiple chronic health problems were significantly associated with reduced HRQoL. The increased number of chronic health problems was also associated with age. When the number of chronic health problems was accounted for, the influence of age diminished. Low income and unemployment were associated with greater decline in HRQoL with respect to increasing number of problems among the respondents in working age.
The impact of increased number of chronic health problems had varying consequences in different age groups. Moreover, sociodemographic and economic factors showed to interact differently with chronic health problems and HRQoL in various age groups. It appears from our results that an assessment and a careful consideration of these factors will be valuable in order to facilitate the interpretation of the effects of cancer and treatment on long-term HRQoL of cancer patients.
通过欧洲癌症研究与治疗组织核心问卷（EORTC QLQ-C30）来研究瑞典普通人群中自我报告的慢性健康问题数量增加时的健康相关生活质量（HRQoL），并研究健康相关生活质量、慢性健康问题与年龄、性别、收入、婚姻状况和就业状况之间的关联。
对4000名年龄在18 - 79岁的成年人进行大规模随机抽样的邮政调查。研究材料包含EORTC QLQ-C30核心问卷，并辅以一份社会人口统计学问卷，该问卷包括有关13种慢性健康问题的问题，从中构建了“无”“很少”“一些”或“很多慢性健康问题”这四类。
多种慢性健康问题与健康相关生活质量降低显著相关。慢性健康问题数量的增加也与年龄有关。当考虑慢性健康问题数量时，年龄的影响减弱。在工作年龄的受访者中，低收入和失业与随着问题数量增加而更大程度的健康相关生活质量下降有关。
慢性健康问题数量增加的影响在不同年龄组中有不同的后果。此外，社会人口统计学和经济因素在不同年龄组中与慢性健康问题和健康相关生活质量的相互作用方式不同。从我们的结果来看，对这些因素进行评估和仔细考虑对于促进对癌症及治疗对癌症患者长期健康相关生活质量影响的解释将是有价值的。
