Gupta P K, Dhar U, Bawa S R
Environ Physiol Biochem. 1975;5(1):49-53.
The effect of malathion (50 mg/kg) and radiation (900R) separately and jointly upon phosphatases and succinic dehydrogenase has been studied in female albino rats. Malathion and radiation when given separately, at the dose levels used in this study, appear to have no effect on acid and alkaline phosphatase of kidney, heart and brain. In preirradiated rats given malathion a significant decrease in phosphatases was observed in kidney and brain tissue after as little as 2 h and the values persisted for up to 24 h. No significant change was observed in heart tissue. At the dose level of 50 mg/kg of malathion, no significant change in succinic dehydrogenase was observed; however, radiation caused a significant increase in succinic dehydrogenase of brain and kidney tissue. In preirradiated rats given malathion the effect appeared to be enhanced in time to a certain degree. One could therefore speculate that simple non-specific stress caused by malathion adds to a similar effort of radiation by reducing phosphatases and enhancing the succinic dehydrogenase enzyme.
研究了马拉硫磷（50毫克/千克）和辐射（900伦琴）单独及联合作用对白化雌性大鼠磷酸酶和琥珀酸脱氢酶的影响。在本研究使用的剂量水平下，单独给予马拉硫磷和辐射时，似乎对肾脏、心脏和大脑的酸性和碱性磷酸酶没有影响。在预先接受辐射的大鼠中给予马拉硫磷后，在仅2小时后就观察到肾脏和脑组织中的磷酸酶显著下降，且这些值持续长达24小时。心脏组织未观察到显著变化。在50毫克/千克的马拉硫磷剂量水平下，未观察到琥珀酸脱氢酶有显著变化；然而，辐射导致脑和肾脏组织中的琥珀酸脱氢酶显著增加。在预先接受辐射的大鼠中给予马拉硫磷，其效果似乎在一定程度上随时间增强。因此可以推测，马拉硫磷引起的简单非特异性应激通过降低磷酸酶和增强琥珀酸脱氢酶，加剧了辐射的类似作用。
