Razinkin S M, Kordenko A N, Ushakov I B, Dukhovich V M
Kosm Biol Aviakosm Med. 1989 Jan-Feb;23(1):51-6.
Hypoxic, thermal and radiation tolerance of rats exposed to hypoxia and overheating for 4 to 22 days was measured. Activities of succinic dehydrogenase, lactate dehydrogenase and alkaline phosphomonoesterase as well as water content in the brain were examined biochemically and histochemically. Brain tolerance and metabolism varied in a phasic manner. Both specific and nonspecific adaptive reactions were identified. A direct correlation was established between hypoxic tolerance and aerobic oxidation decrease as well as enzyme-dependent transport in cerebral vascular walls. A relationship between CNS radiation tolerance and permeability of the blood-brain barrier was detected.
测定了暴露于缺氧和过热环境4至22天的大鼠的缺氧、热和辐射耐受性。通过生化和组织化学方法检测了琥珀酸脱氢酶、乳酸脱氢酶和碱性磷酸单酯酶的活性以及大脑中的含水量。大脑耐受性和代谢呈阶段性变化。识别出了特异性和非特异性适应性反应。建立了缺氧耐受性与有氧氧化减少以及脑血管壁中酶依赖性转运之间的直接相关性。检测到中枢神经系统辐射耐受性与血脑屏障通透性之间的关系。
