卡里希南二萜类化合物全合成的进展。

Progress toward the total synthesis of kalihinane diterpenoids.

作者信息

White R D, Wood J L

机构信息

Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.

出版信息

Org Lett. 2001 Jun 14;3(12):1825-7. doi: 10.1021/ol015828k.

DOI:10.1021/ol015828k

PMID:11405721

Abstract

[see structure]. Studies toward the total synthesis of marine diterpenoids isolated from Acanthella sp., e.g., kalihinol A, are described. Efficient construction of the functionalized trans-decalin core (11) is achieved through intramolecular Diels-Alder cyclization followed by diastereoselective epoxidation and aziridination.

摘要

[见结构]。描述了对从棘海绵属分离得到的海洋二萜类化合物（如卡里希诺醇A）进行全合成的研究。通过分子内狄尔斯-阿尔德环化反应，随后进行非对映选择性环氧化和氮丙啶化反应，实现了官能化反式十氢化萘核心结构（11）的有效构建。