State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zuchongzhi Road 555 Zhangjiang Hi-Tech Park, Shanghai 201203, China.
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Mar Drugs. 2019 Jan 16;17(1):56. doi: 10.3390/md17010056.
A detailed chemical investigation of two South China Sea nudibranchs and , as well as their possible sponge-prey , led to the isolation of one new nitrogenous cadinane-type sesquiterpenoid xidaoisocyanate A (), one new naturally occurring nitrogen-containing kalihinane-type diterpenoid bisformamidokalihinol A (), along with 17 known nitrogenous terpenoids (⁻, ⁻). The structures of all the isolates were elucidated by detailed spectroscopic analysis and by the comparison of their spectroscopic data with those reported in the literature. In addition, the absolute stereochemistry of the previously reported axiriabiline A () was determined by X-ray diffraction (XRD) analysis. In a bioassay, the bisabolane-type sesquiterpenoids , , and exhibited cytotoxicity against several human cancer cell lines.
对南海两种裸鳃目软体动物 和 及其可能的海绵猎物进行了详细的化学研究，从中分离得到了一个新的含氮卡丹烷型倍半萜烯异氰酸酯 A ()，一个新的天然含氮卡里烯型二酰胺卡里醇 A ()，以及 17 个已知的含氮萜类化合物 (⁻, ⁻)。通过详细的光谱分析以及与文献报道的数据进行比较，确定了所有分离物的结构。此外，通过 X 射线衍射 (XRD) 分析确定了先前报道的 axiriabiline A ()的绝对立体化学。在生物测定中，倍半萜烯类化合物 、 和 对几种人类癌细胞系表现出细胞毒性。
