补体依赖性过敏反应。
Complement-dependent anaphylactic reactions.
作者信息
Tom B H, Raffel S
出版信息
Infect Immun. 1975 Jun;11(6):1284-90. doi: 10.1128/iai.11.6.1284-1290.1975.
Abstract
The concept of elicitation of reactions of anaphylactic type by non-tissue-fixing antibody, through activation of complement and release of anaphylatoxins by antigen-antibody complexes in vivo, is not clearly defined by published evidence. Experimental data are presented to demonstrate that guinea pig immunoglobulin G2 (noncytotropic) complexed with antigen in vitro elicits dermal reactions in guinea pigs, and that pretreatment of animals with complement-inactivating cobra venom factor diminishes such reactions. The various pathways through which immediate hypersensitive reactions may occur are discussed.
摘要
关于非组织固定抗体通过补体激活和体内抗原抗体复合物释放过敏毒素引发过敏反应类型的概念，现有已发表的证据并未明确界定。本文呈现的实验数据表明，豚鼠免疫球蛋白G2（非亲细胞性）在体外与抗原结合后可引发豚鼠皮肤反应，且用补体灭活的眼镜蛇毒因子预处理动物可减轻此类反应。文中还讨论了可能发生速发型过敏反应的各种途径。
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