Mueck A O, Seeger H, Wallwiener D
Section of Gynecological Endocrinology and Menopause, Department of Obstetrics and Gynecology, University of Tuebingen, Germany.
Exp Clin Endocrinol Diabetes. 2001;109(3):181-3. doi: 10.1055/s-2001-14843.
The effect of the synthetic statin fluvastatin was investigated on the concentrations of endothelial nitric oxide synthase (eNOS) and of soluble adhesion molecules in human vascular endothelial cell cultures. Fluvastatin was able to increase dose-dependently eNOS concentration. In addition, fluvastatin reduced concentrations of E-Selectin and ICAM-1. These results further support the evidence that statins elicit important effects on the vascular endothelium which may contribute to the reduction of morbidity and mortality of cardiovascular diseases.
研究了合成他汀类药物氟伐他汀对人血管内皮细胞培养物中内皮型一氧化氮合酶（eNOS）浓度和可溶性黏附分子浓度的影响。氟伐他汀能够剂量依赖性地增加eNOS浓度。此外，氟伐他汀降低了E-选择素和细胞间黏附分子-1（ICAM-1）的浓度。这些结果进一步支持了他汀类药物对血管内皮产生重要作用的证据，这可能有助于降低心血管疾病的发病率和死亡率。
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