Institute of Medical Biochemistry, Clinical Center of Serbia and Farmaceutical Faculty, University of Belgrade, Belgrade, Serbia.
Biochem Med (Zagreb). 2012;22(1):39-48. doi: 10.11613/bm.2012.005.
Age-related macular degeneration (AMD) is a complex, degenerative and progressive disease involving the multiple genetic and environmental factors that can result in severe visual loss. The etiology of AMD is not well understood. Many theories exist and feature mechanisms of oxidative stress, atherosclerotic-like changes, genetic predisposition and inflammation. The most recent clinical studies appointed to a great role of inflammation and C-reactive protein (CRP) in the pathogenesis of AMD. There is a large body of evidence indicating the association of CRP with endothelial dysfunction, oxidative stress and production of reactive oxygen species (ROS), as well as with lipid status disorder in AMD patients. According to recent studies, CRP is definitely not only the inflammatory marker but also a mediator of development of the vascular disorders in the retinal circulation. The results obtained from the present studies may help our understanding the pathogenesis of the retinal vascular disease associated with high levels of CRP.
年龄相关性黄斑变性（AMD）是一种复杂的、退行性的和进行性疾病，涉及多种遗传和环境因素，可导致严重的视力丧失。AMD 的病因尚不清楚。存在许多理论，其特征在于氧化应激、动脉粥样硬化样变化、遗传易感性和炎症的机制。最近的临床研究指出炎症和 C 反应蛋白（CRP）在 AMD 发病机制中的重要作用。大量证据表明 CRP 与 AMD 患者的内皮功能障碍、氧化应激和活性氧（ROS）的产生以及脂质状态紊乱有关。根据最近的研究，CRP 不仅是炎症标志物，还是视网膜循环中血管紊乱发展的介质。本研究获得的结果可能有助于我们了解与 CRP 水平升高相关的视网膜血管疾病的发病机制。
