葡萄籽提取物和槲皮素对高危人群心血管及内皮参数的影响。
Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects.
作者信息
Clifton Peter M
出版信息
J Biomed Biotechnol. 2004;2004(5):272-278. doi: 10.1155/S1110724304403088.
Abstract
Grape seed extract (GSE) has in vitro antioxidant activity but whether or not it works in vivo is not clear. In a fully randomised, crossover trial with 4-week treatment periods on 36 men and women with above-average vascular risk, we aimed to demonstrate that 2 g/day of GSE (1 g of polyphenols) alone, or with 1 g/day of added quercetin in yoghurt, favourably alters vascular function, endothelial function, and degree of oxidative damage in comparison to a control yoghurt. GSE alone improved flow-mediated dilatation determined ultrasonically by an absolute $1.1$ % compared with control. There was no effect of the combination of GSE with quercetin. No other blood or urine measure was altered. Thus sufficient polyphenols from GSE appear to be absorbed to influence endothelial nitric oxide production, and GSE has the potential to favourably influence vascular function.
摘要
葡萄籽提取物（GSE）具有体外抗氧化活性，但它在体内是否起作用尚不清楚。在一项针对36名血管风险高于平均水平的男性和女性进行的、为期4周治疗期的完全随机交叉试验中，我们旨在证明，与对照酸奶相比，每天2克GSE（1克多酚）单独使用，或在酸奶中添加1克/天的槲皮素，可有利地改变血管功能、内皮功能和氧化损伤程度。单独使用GSE可使超声测定的血流介导的扩张绝对改善1.1%，与对照相比。GSE与槲皮素联合使用没有效果。其他血液或尿液指标均未改变。因此，GSE中足够的多酚似乎被吸收以影响内皮一氧化氮的产生，并且GSE有可能有利地影响血管功能。
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