Morise T, Takeuchi Y, Takeda R
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Horm Res. 1994;41(5-6):218-21. doi: 10.1159/000183927.
The genetic basis of essential hypertension is still uncertain. Because renin is thought to be a candidate gene for essential hypertension, a prospective study was conducted to compare the frequency of renin gene HindIII restriction fragment length polymorphism (RFLP) in normotensive and hypertensive subjects without (HTG-) and with a genetic predisposition to essential hypertension (HTG+). The frequency of the 9.0-kb fragment was significantly (p < 0.05) higher in the HTG+ group than in the normotensive and HTG- groups. An association between renin RFLP and hypertension in man was shown for the first time. It is suggested that a gene for blood pressure regulation has been localized to a part of the genome close to, or identical to, the renin locus.
原发性高血压的遗传基础仍不明确。由于肾素被认为是原发性高血压的一个候选基因，因此进行了一项前瞻性研究，以比较肾素基因HindIII限制性片段长度多态性（RFLP）在血压正常者、无原发性高血压遗传易感性的高血压患者（HTG-）和有原发性高血压遗传易感性的高血压患者（HTG+）中的频率。HTG+组中9.0-kb片段的频率显著高于血压正常组和HTG-组（p<0.05）。首次显示了肾素RFLP与人高血压之间的关联。提示血压调节基因已定位到基因组中靠近肾素基因座或与其相同的区域。
