Papageorgiou C, Liappas I, Asvestas P, Vasios C, Matsopoulos G K, Nikolaou C, Nikita K S, Uzunoglu N, Rabavilas A
Department of Psychiatry, Eginition Hospital, University of Athens, Greece.
Neuroreport. 2001 Jun 13;12(8):1773-8. doi: 10.1097/00001756-200106130-00051.
The P600 component of event-related potentials, believed to be generated by anterior cingulate gyrus and basal ganglia, is considered as an index of aspects of second-pass parsing processes of information processing, having much in common with working memory (WM) systems. Moreover, dysfunction of these brain structures as well as WM deficits have been implicated in the pathophysiology of opioid addicts. The present study is focused on P600 elicited during a WM test in twenty heroin addicts with prolonged abstinence compared with an equal number of healthy controls. The results showed significantly prolonged latencies at right hemisphere, specifically at Fp2 abduction. Moreover, memory performance of patients did not differ from that of normal controls. These findings may indicate that abstinent heroin addicts manifest abnormal aspects of second-pass parsing processes as are reflected by the P600 latencies, elicited during a WM test. Additionally, the P600 might serve as a valuable investigative tool for a more comprehensive understanding of the neurobiological substrate of drug abuse.
事件相关电位的P600成分，据信是由前扣带回和基底神经节产生的，被视为信息处理的二次解析过程各方面的一个指标，与工作记忆（WM）系统有许多共同之处。此外，这些脑结构的功能障碍以及WM缺陷已被认为与阿片类成瘾者的病理生理学有关。本研究聚焦于20名长期戒毒的海洛因成瘾者在进行WM测试时诱发的P600，并与同等数量的健康对照者进行比较。结果显示，右半球，特别是Fp2外展位的潜伏期显著延长。此外，患者的记忆表现与正常对照者并无差异。这些发现可能表明，戒毒后的海洛因成瘾者表现出二次解析过程的异常方面，如在WM测试中诱发的P600潜伏期所反映的那样。此外，P600可能是一种有价值的研究工具，有助于更全面地了解药物滥用的神经生物学基础。
