Tamura N, Dong Y, Sui L, Tai Y, Sugimoto K, Nagahata S, Tokuda M
Department of Oral and Maxillofacial Surgery, Kagawa Medical University, Kagawa, 761-0793, Japan.
J Laryngol Otol. 2001 May;115(5):400-6. doi: 10.1258/0022215011907749.
An immunohistochemical study of both p27 and proliferating cell nuclear antigen (PCNA) was performed on 102 cases of laryngeal squamous cell carcinomas (LSCCs), and large variations in p27 expression were found among the tumours. Reduced expression of p27 was revealed in 54 (52.9 per cent) cases and correlated with tumour size, lymph node metastasis, and clinical stage, but did not correlate with age, sex, tumour site, or tumour grade. A significant positive correlation was found between the percentage of loss of p27 expression and the PCNA index (r = 0.844, p < 0.0001). Reduced expression of p27 was significantly correlated with both reducing disease-free and overall survival by univariate analysis. By multivariate analysis, reduced expression of p27, tumour grade, tumour size, lymph node metastasis as well as clinical stage were independent prognostic factors for overall survival of LSCCs. These findings indicate that reduced expression of p27 may be correlated with the malignant biological behaviour of LSCCs.
对102例喉鳞状细胞癌（LSCC）进行了p27和增殖细胞核抗原（PCNA）的免疫组织化学研究，发现肿瘤之间p27表达存在很大差异。54例（52.9%）病例显示p27表达降低，且与肿瘤大小、淋巴结转移和临床分期相关，但与年龄、性别、肿瘤部位或肿瘤分级无关。p27表达缺失百分比与PCNA指数之间存在显著正相关（r = 0.844，p < 0.0001）。单因素分析显示，p27表达降低与无病生存期和总生存期缩短均显著相关。多因素分析表明，p27表达降低、肿瘤分级、肿瘤大小、淋巴结转移以及临床分期是LSCC总生存期的独立预后因素。这些发现表明，p27表达降低可能与LSCC的恶性生物学行为相关。
