Auclair K, Kennedy J, Hutchinson C R, Vederas J C
Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.
Bioorg Med Chem Lett. 2001 Jun 18;11(12):1527-31. doi: 10.1016/s0960-894x(01)00290-6.
Investigation of the post-PKS biosynthetic steps to the cholesterol-lowering agent lovastatin (1) using an Aspergillus terreus strain with a disrupted lovC gene, which is essential for formation of 4a,5-dihydromonacolin L (3), shows that 7 and 3 are precursors to 1, and demonstrates that lovastatin diketide synthase (lovF protein) does not require lovC.
利用一株土曲霉（Aspergillus terreus）菌株对降胆固醇药物洛伐他汀（1）的聚酮合酶（PKS）后生物合成步骤进行研究，该菌株的lovC基因被破坏，而lovC基因对于4a,5-二氢莫纳可林L（3）的形成至关重要。研究表明，7和3是1的前体，并证明洛伐他汀二酮合酶（lovF蛋白）不需要lovC。
