LovG：洛伐他汀生物合成中二氢茉莉酮酸内酯释放和洛伐他汀九酮合酶周转所需的硫酯酶。
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.
机构信息
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
出版信息
Angew Chem Int Ed Engl. 2013 Jun 17;52(25):6472-5. doi: 10.1002/anie.201302406. Epub 2013 May 7.
Abstract
The cryptic thioesterase LovG is found to be responsible for product release from the lovastatin nonaketide synthase (LNKS or LovB). The same enzyme also helps improving turnover of LovB through hydrolysis of incorrectly tailored intermediates.
摘要
隐秘硫酯酶LovG 被发现负责洛伐他汀九酮合酶 (LNKS 或 LovB) 的产物释放。该酶还通过水解不合适的中间体来帮助提高 LovB 的周转率。
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