天然[4 + 2]环化酶
Natural [4 + 2]-Cyclases.
作者信息
Jeon Byung-Sun, Wang Shao-An, Ruszczycky Mark W, Liu Hung-Wen
机构信息
Department of Chemistry and ‡Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin , Austin, Texas 78712, United States.
出版信息
Chem Rev. 2017 Apr 26;117(8):5367-5388. doi: 10.1021/acs.chemrev.6b00578. Epub 2016 Dec 1.
Abstract
[4 + 2]-Cycloadditions are increasingly being recognized in the biosynthetic pathways of many structurally complex natural products. A relatively small collection of enzymes from these pathways have been demonstrated to increase rates of cyclization and impose stereochemical constraints on the reactions. While mechanistic investigation of these enzymes is just beginning, recent studies have provided new insights with implications for understanding their biosynthetic roles, mechanisms of catalysis, and evolutionary origin.
摘要
[4 + 2]环加成反应在许多结构复杂的天然产物的生物合成途径中越来越受到认可。已证明这些途径中相对少量的一组酶能提高环化速率并对反应施加立体化学限制。虽然对这些酶的机制研究才刚刚开始，但最近的研究提供了新的见解，有助于理解它们的生物合成作用、催化机制和进化起源。
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