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Natural [4 + 2]-Cyclases.
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Sesquiterpene synthases: passive catalysts or active players?
Nat Prod Rep. 2012 Jan;29(1):60-71. doi: 10.1039/c1np00060h. Epub 2011 Nov 8.
3
Genome-Based Discovery of an Unprecedented Cyclization Mode in Fungal Sesterterpenoid Biosynthesis.
J Am Chem Soc. 2016 Aug 10;138(31):10011-8. doi: 10.1021/jacs.6b05799. Epub 2016 Aug 2.
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The viability of nitrone-alkene (3 + 2) cycloadditions in alkaloid biosynthesis.
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Nonenzymatic Reactions in Natural Product Formation.
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6
Terpenoid biosynthesis off the beaten track: unconventional cyclases and their impact on biomimetic synthesis.
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The asymmetric hetero-Diels-Alder reaction in the syntheses of biologically relevant compounds.
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Enantioselective Total Syntheses of Various Amphilectane and Serrulatane Diterpenoids via Cope Rearrangements.
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Biocatalyzed and Photochemical Formal [2+2] Cycloaddition of Euphoboetirane A: A Route to a Fused Pentacyclic Diterpene Skeleton.
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3
Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis.
Nat Catal. 2019 Oct 14;2(11):1045-1054. doi: 10.1038/s41929-019-0351-2.
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Advances on the biosynthesis of pyridine rings.
Eng Microbiol. 2022 Dec 13;3(2):100064. doi: 10.1016/j.engmic.2022.100064. eCollection 2023 Jun.
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A specialized role played by a redox cofactor.
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Delineation of the complete reaction cycle of a natural Diels-Alderase.
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8
Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis.
Nat Commun. 2024 Jul 10;15(1):5779. doi: 10.1038/s41467-024-50142-1.
9
Expanding chemistry through in vitro and in vivo biocatalysis.
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10
Visible-light-enabled stereoselective synthesis of functionalized cyclohexylamine derivatives [4 + 2] cycloadditions.
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本文引用的文献

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Mechanistic insights into Diels-Alder reactions in natural product biosynthesis.
Curr Opin Chem Biol. 2016 Dec;35:117-123. doi: 10.1016/j.cbpa.2016.09.015. Epub 2016 Sep 30.
2
Enzymatic [4+2] Cycloadditions in the Biosynthesis of Spirotetramates and Spirotetronates.
Methods Enzymol. 2016;575:39-63. doi: 10.1016/bs.mie.2016.02.019. Epub 2016 Mar 16.
3
Recent advances of Diels-Alderases involved in natural product biosynthesis.
J Antibiot (Tokyo). 2016 Jul;69(7):500-6. doi: 10.1038/ja.2016.67. Epub 2016 Jun 15.
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The Catalytic Mechanism of a Natural Diels-Alderase Revealed in Molecular Detail.
J Am Chem Soc. 2016 May 18;138(19):6095-8. doi: 10.1021/jacs.6b00232. Epub 2016 May 6.
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Nature's Strategy for Catalyzing Diels-Alder Reaction.
Cell Chem Biol. 2016 Apr 21;23(4):429-30. doi: 10.1016/j.chembiol.2016.04.002.
8
Dynamically Complex [6+4] and [4+2] Cycloadditions in the Biosynthesis of Spinosyn A.
J Am Chem Soc. 2016 Mar 23;138(11):3631-4. doi: 10.1021/jacs.6b00017. Epub 2016 Mar 9.
9
Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4.
Cell Chem Biol. 2016 Mar 17;23(3):352-60. doi: 10.1016/j.chembiol.2016.01.005. Epub 2016 Feb 11.
10
Recent advances in understanding the enzymatic reactions of [4+2] cycloaddition and spiroketalization.
Curr Opin Chem Biol. 2016 Apr;31:95-102. doi: 10.1016/j.cbpa.2016.01.020. Epub 2016 Feb 9.

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