Brecklin Carolyn S., Bauman Jerry L.
Department of Medicine, Sections of Nephrology and Cardiology and the Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL.
J Clin Hypertens (Greenwich). 1999 Nov;1(3):212-217.
Cocaine, a naturally occurring alkaloid, has increasingly been implicated in a myriad of medical complications. The majority of these relate to cardiovascular effects of the drug, a potent sympathomimetic. In addition, cocaine has effects on endothelin-1, the sodium channel, and nitric oxide which further enhance its untoward cardiovascular effects. The cardiovascular effects of cocaine include myocardial ischemia or infarction, ventricular arrhythmias and sudden death, cardiomyopathy, cerebral infarction or hemorrhage, and acute hypertension. Although hypertension has been described in the offspring of cocaine using mothers, two recent studies have not found an increased prevalence of chronic hypertension in adults. Nonetheless, long term abuse of cocaine can lead to the various forms of target organ damage usually associated with untreated essential hypertension, presumably due to frequent intermittent and severe elevations in blood pressure. (c)1999 by Le Jacq Communications, Inc.
可卡因是一种天然存在的生物碱，越来越多地与众多医学并发症相关联。其中大多数与该药物的心血管效应有关，它是一种强效拟交感神经药。此外，可卡因还会影响内皮素 -1、钠通道和一氧化氮，这进一步增强了其不良的心血管效应。可卡因的心血管效应包括心肌缺血或梗死、室性心律失常和猝死、心肌病、脑梗死或出血以及急性高血压。虽然在使用可卡因的母亲的后代中曾有高血压的描述，但最近的两项研究并未发现成年人中慢性高血压的患病率增加。尽管如此，长期滥用可卡因会导致通常与未经治疗的原发性高血压相关的各种形式的靶器官损害，可能是由于血压频繁间歇性严重升高所致。(c)1999 年由 Le Jacq 通信公司版权所有
