Chmiel James, Chojdak-Łukasiewicz Justyna, Leszek Jerzy
Institute of Neurofeedback and tDCS Poland, 70-393 Szczecin, Poland.
Department and Clinic of Neurology, Wrocław Medical University, 54-235 Wrocław, Poland.
J Clin Med. 2023 Oct 13;12(20):6511. doi: 10.3390/jcm12206511.
Cocaine addiction is a significant problem worldwide. The development of addiction involves a reward system, which consists of certain brain regions like the ventral tegmental area, nucleus accumbens, and prefrontal cortex. Currently, there are no approved medications for treating cocaine dependence, so researchers are actively searching for effective treatments that can impact the brain. One potential treatment under investigation is transcranial direct current stimulation (tDCS), a non-invasive method of stimulating the brain to modulate its activity. In this review, we explore the use of tDCS in treating cocaine addiction. We found nine relevant articles via a literature search, and the results indicate that applying tDCS to the right dorsolateral prefrontal cortex (DLPFC) holds promise for reducing drug cravings in individuals with cocaine addiction. The review also discusses the possible mechanisms by which tDCS works and provides recommendations for future research in this field.
可卡因成瘾是一个全球性的重大问题。成瘾的发展涉及一个奖赏系统，该系统由某些脑区组成，如腹侧被盖区、伏隔核和前额叶皮质。目前，尚无获批用于治疗可卡因依赖的药物，因此研究人员正在积极寻找能够影响大脑的有效治疗方法。正在研究的一种潜在治疗方法是经颅直流电刺激（tDCS），这是一种刺激大脑以调节其活动的非侵入性方法。在本综述中，我们探讨了tDCS在治疗可卡因成瘾中的应用。我们通过文献检索找到了9篇相关文章，结果表明，将tDCS应用于右侧背外侧前额叶皮质（DLPFC）有望减少可卡因成瘾者的药物渴望。该综述还讨论了tDCS起作用的可能机制，并为该领域的未来研究提供了建议。
