Christensen P B, Krarup H B, Niesters H G, Norder H, Georgsen J
Department of Clinical Immunology, Odense University Hospital, Aalborg Hospital, Denmark.
Eur J Epidemiol. 2000;16(11):1043-9. doi: 10.1023/a:1010833917242.
In order to determine the prevalence and incidence of bloodborne viral infections among prisoners, we conducted a prospective study in a Danish medium security prison for males. The prisoners were offered an interview and blood test for hepatitis and human immunodeficiency virus HIV at inclusion as well as at release from prison or end of study. Of 403 prisoners available 325 (79%) participated in the initial survey and for 142 (44%) a follow-up test was available. 43% (140/325) of the participants were injecting drug users (IDUs) of whom 64% were positive for hepatitis B (HBV) and 87% for hepatitis C (HCV) markers. No cases of HIV or human T lymphotropic virus (HTLV) were found. 32% of all prisoners could transmit HBV and/or HCV by blood contact. 70% of IDUs had shared injecting equipment, and 60% had injected inside prison. Only 2% of IDUs were vaccinated against HBV. Duration of injecting drug use, numbers of imprisonments, and injecting in prison were independently and positively associated with the presence of HBV antibodies among IDUs by logistic regression analysis. The HBV incidence was 16/100 PY (95% CI: 2-56/100 PY) and the HCV incidence 25/100 PY (1-140) among injecting drug users (IDUs). We conclude that IDUs in prison have an incidence of hepatitis B and C 100 times higher than reported in the general Danish population. They should be vaccinated against hepatitis B and new initiatives to stop sharing of injecting equipment in and outside prison is urgently needed.
为了确定囚犯中血源病毒感染的患病率和发病率,我们在丹麦一所中等安全级别的男性监狱进行了一项前瞻性研究。在囚犯入狱时以及出狱或研究结束时,为他们提供了关于肝炎和人类免疫缺陷病毒(HIV)的访谈及血液检测。在403名可参与研究的囚犯中,325人(79%)参与了初始调查,其中142人(44%)进行了随访检测。参与者中有43%(140/325)为注射吸毒者(IDU),其中64%的人乙肝病毒(HBV)标志物呈阳性,87%的人丙型肝炎病毒(HCV)标志物呈阳性。未发现HIV或人类嗜T淋巴细胞病毒(HTLV)感染病例。所有囚犯中有32%可能通过血液接触传播HBV和/或HCV。70%的注射吸毒者曾共用注射器具,60%在监狱内注射过毒品。只有2%的注射吸毒者接种过乙肝疫苗。通过逻辑回归分析,注射吸毒的持续时间、入狱次数和在监狱内注射与注射吸毒者中HBV抗体的存在独立且呈正相关。注射吸毒者中HBV发病率为16/100人年(95%置信区间:2 - 56/100人年),HCV发病率为25/100人年(1 - 140)。我们得出结论,监狱中的注射吸毒者乙肝和丙肝的发病率比丹麦普通人群报告的发病率高100倍。他们应该接种乙肝疫苗,并且迫切需要采取新举措来阻止在监狱内外共用注射器具的行为。