特应性皮炎婴儿血清硝酸盐水平升高。
Increased serum nitrate levels in infants with atopic dermatitis.
作者信息
Taniuchi S, Kojima T, Hara Mt K, Yamamoto A, Sasai M, Takahashi H, Kobayashi Y
机构信息
Department of Paediatrics, Kansai Medical University, Osaka, Japan.
出版信息
Allergy. 2001 Jul;56(7):693-5. doi: 10.1034/j.1398-9995.2001.00131.x.
BACKGROUND
The pathogenesis of atopic dermatitis (AD) is still unknown. A recent study has shown that inducible nitric oxide synthase (iNOS) is expressed in the atopic skin lesion, suggesting the involvement of nitric oxide in the skin inflammation of AD. The purpose of the study was to examine serum nitrate (NO3) levels in relation to the disease severity in children with AD.
METHODS
Serum nitrate levels were assessed in relation to the skin scores in 88 patients with atopic dermatitis (AD) (aged 0.4-8 years: mean+/-SD, 2.2+/-1.9, 41 boys and 47 girls) and 12 nonatopic children (aged 0.8-4 years: mean+/-SD, 1.8+/-0.9, seven boys and five girls).
RESULTS
Serum nitrate levels of patients with AD were significantly increased as compared to nonatopic controls and were also correlated with the disease severity. The skin scores were significantly correlated with serum nitrate levels as well as peripheral eosinophil counts.
CONCLUSION
Our results indicate that nitric oxide may be involved in the pathogenesis of vasodilation and erythema in AD skin.
背景
特应性皮炎（AD）的发病机制仍不清楚。最近一项研究表明，诱导型一氧化氮合酶（iNOS）在特应性皮肤病变中表达，提示一氧化氮参与了AD的皮肤炎症。本研究的目的是检测AD患儿血清硝酸盐（NO3）水平与疾病严重程度的关系。
方法
评估88例特应性皮炎（AD）患儿（年龄0.4 - 8岁：均值±标准差，2.2±1.9，41名男孩和47名女孩）和12名非特应性儿童（年龄0.8 - 4岁：均值±标准差，1.8±0.9，7名男孩和5名女孩）的血清硝酸盐水平与皮肤评分的关系。
结果
与非特应性对照组相比，AD患者的血清硝酸盐水平显著升高，且与疾病严重程度相关。皮肤评分与血清硝酸盐水平以及外周嗜酸性粒细胞计数显著相关。
结论
我们的结果表明，一氧化氮可能参与了AD皮肤血管舒张和红斑的发病机制。
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