从韩国海绵 Plakortis simplex 中分离得到的新成分。
New constituents from the Korean sponge Plakortis simplex.
机构信息
Department of Oceanography, Kunsan National University, Jeonbuk 573-701, Korea.
出版信息
Mar Drugs. 2013 Nov 5;11(11):4407-18. doi: 10.3390/md11114407.
Abstract
Six new cyclic peroxides (1-6) were isolated from the Korean sponge Plakortis simplex, along with two new alkylpyridinium alkaloids (7 and 8). The structures of these compounds were completely determined by a combination of NMR analysis and chemical reactions. Compounds 1-6 exhibited cytotoxic/antifungal activities against RAW264.7 cells and Candida albicans.
摘要
从韩国海绵 Plakortis simplex 中分离得到了 6 个新的环过氧化物（1-6）和 2 个新的烷基吡啶生物碱（7 和 8）。这些化合物的结构通过 NMR 分析和化学反应的组合完全确定。化合物 1-6 对 RAW264.7 细胞和白色念珠菌表现出细胞毒性/抗真菌活性。
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