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尤卡坦半岛（墨西哥）海洋生物的抗真菌潜力对医学重要的 spp.

Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important spp.

机构信息

Departamento de Biología Marina, Universidad Autónoma de Yucatán, Km. 15.5, Carretera Mérida-Xmatkuil, A.P. 4-116 Itzimná, Merida CP 97100, Mexico.

Escuela Nacional de Estudios Superiores Unidad Mérida (ENES Mérida), Universidad Nacional Autónoma de México (UNAM), Carretera Mérida-Tetiz km 4.5, Tablaje, Catastral No. 6998, Municipio de Ucú, Ucú CP 97357, Mexico.

出版信息

Molecules. 2023 Jan 6;28(2):606. doi: 10.3390/molecules28020606.

DOI:10.3390/molecules28020606
PMID:36677663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9863849/
Abstract

Invasive fungal infections represent a global health threat. They are associated with high mortality and morbidity rates, partly due to the ineffectiveness of the available antifungal agents. The rampant increase in infections recalcitrant to the current antifungals has worsened this scenario and made the discovery of new and more effective antifungals a pressing health issue. In this study, 65 extracts from marine organisms of the Yucatan Peninsula, Mexico, were screened for antifungal activity against and , two of the most prevalent fungal species that cause nosocomial invasive fungal infections worldwide. A total of 51 sponges, 13 ascidians and 1 gorgonian were collected from the coral reef and mangrove forest in the Yucatan Peninsula (Mexico) and extracted with organic solvents. Nine crude extracts showed potent antifungal activity, of which four extracts from the sponge species , , and had promising activity against spp. Bioassay-guided fractionation of the extract revealed the remarkable fungicidal activity of some fractions. Analysis of the chemical composition of one of the most active fractions by UHPLC-HRMS and NMR indicated the presence of mirabilin B and penaresidin B, and their contribution to the observed antifungal activity is discussed. Overall, this work highlights marine organisms of the Yucatan Peninsula as important reservoirs of natural products with promising fungicidal activity, which may greatly advance the treatment of invasive fungal infections, especially those afflicting immunosuppressed patients.

摘要

侵袭性真菌感染是全球性的健康威胁。它们与高死亡率和发病率有关，部分原因是现有的抗真菌药物无效。目前抗真菌药物无效的感染呈猖獗增长，使这一情况恶化，发现新的、更有效的抗真菌药物成为紧迫的健康问题。在这项研究中，从墨西哥尤卡坦半岛的海洋生物中筛选了 65 种提取物，以检测它们对 和 的抗真菌活性，这两种真菌是全球医院获得性侵袭性真菌感染最常见的病原体。从尤卡坦半岛的珊瑚礁和红树林中采集了 51 种海绵、13 种海鞘和 1 种柳珊瑚，并用有机溶剂提取。9 种粗提物表现出很强的抗真菌活性，其中 4 种来自海绵属 的提取物对 spp. 表现出良好的活性。对 提取物进行生物活性导向的分离，揭示了一些馏分的显著杀菌活性。用 UHPLC-HRMS 和 NMR 对其中一个活性最强的馏分进行化学成分分析，表明存在 mirabilin B 和 penaresidin B，讨论了它们对观察到的抗真菌活性的贡献。总的来说，这项工作强调了尤卡坦半岛的海洋生物是具有潜在杀菌活性的天然产物的重要来源，这可能极大地推进侵袭性真菌感染的治疗，特别是对免疫抑制患者的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3be/9863849/6d5fa2e3eeb6/molecules-28-00606-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3be/9863849/eb94a6314827/molecules-28-00606-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3be/9863849/6d5fa2e3eeb6/molecules-28-00606-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3be/9863849/a447ca87563b/molecules-28-00606-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3be/9863849/708aaf90ad12/molecules-28-00606-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3be/9863849/1c358e96e135/molecules-28-00606-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3be/9863849/c992795870a1/molecules-28-00606-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3be/9863849/edd88cf127b8/molecules-28-00606-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3be/9863849/bfc13a5d471d/molecules-28-00606-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3be/9863849/eb94a6314827/molecules-28-00606-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3be/9863849/6d5fa2e3eeb6/molecules-28-00606-g010.jpg

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本文引用的文献

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Application of marine natural products in drug research.海洋天然产物在药物研究中的应用。
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The Virulence Factors and Clinical Manifestations of Infection.感染的毒力因子与临床表现
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Batzelladine D and norbatzelladine L purified from marine sponge Monanchora arbuscula induce the reversal of fluconazole.从海洋海绵 Monanchora arbuscula 中分离得到的 batzelladine D 和 norbatzelladine L 可诱导氟康唑逆转。
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In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge , against .体外和体内评估从海绵中分离得到的生物碱溴代海因对 的疗效。
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