Regev A, Schiff E R
Division of Hepatology, Center for Liver Diseases, University of Miami School of Medicine, Miami, Florida, USA.
Gastroenterol Clin North Am. 2001 Jun;30(2):547-63, x-xi. doi: 10.1016/s0889-8553(05)70195-3.
Despite several morphologic and functional changes that have been described in the aging liver, most relevant studies fail to identify a significant age-related deficit in liver function in humans. One of the important age-related changes is a decrease in regenerative capacity, which may partly explain the impaired recovery after severe viral and toxic injury in the elderly. Nevertheless, livers from older subjects are used successfully for transplantation. Substantial morbidity and mortality in the elderly is attributable to liver diseases, and the number of patients older than 65 years of age with chronic liver disease is increasing rapidly. Although there are no liver diseases specific to advanced age, the presentation, clinical course and management of liver diseases in the elderly may differ in important respects from those of younger individuals.
尽管在衰老肝脏中已描述了多种形态学和功能变化，但大多数相关研究未能确定人类肝脏功能存在与年龄相关的显著缺陷。与年龄相关的重要变化之一是再生能力下降，这可能部分解释了老年人在遭受严重病毒和毒性损伤后恢复受损的原因。然而，老年受试者的肝脏仍成功用于移植。老年人的高发病率和死亡率归因于肝脏疾病，65岁以上慢性肝病患者的数量正在迅速增加。虽然没有特定于高龄的肝脏疾病，但老年人肝脏疾病的表现、临床过程和管理在重要方面可能与年轻人不同。
